Icariin induces the expression of toll-like receptor 9 in Ana-1 murine macrophages

文献类型: 外文期刊

第一作者: Li, Li

作者: Li, Li;Miao, Jianhua;Xu, Yongli;Peng, Lina;Qiu, Yafeng;Gao, Xiaoqi;Shi, Zixue;Shao, Donghua;Ma, Zhiyong;Zhou, Ying

作者机构:

关键词: Herba epimedii;Icariin;Innate immunity;Toll-like receptor 9

期刊名称:PHYTOTHERAPY RESEARCH ( 影响因子:5.878; 五年影响因子:5.286 )

ISSN:

年卷期:

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收录情况: SCI

摘要: Icariin is the major pharmacologically active compound of Herba epimedii which has been used as a tonic, aphrodisiac and an antirheumatic in traditional Chinese medicine. This study analysed the effect of icariin on the expression of Toll-like receptor 9 (TLR9) which plays an important role in regulation of the innate immune response. Stimulation of Ana-1 murine macrophages with icariin induced a significant dose-dependent expression of TLR9, and its mRNA expression which increased from 3 h post-treatment was approximately fivefold that of DMSO-treated cells. Several molecules, such as myeloid differentiation factor 88, tumor necrosis factor-á and interleukin 6, which are involved in the TLR9 downstream signaling pathway, were also significantly up-regulated in response to icariin stimulation. Our findings demonstrated that icariin is able to induce the expression of TLR9.

分类号: R243

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