Sesquiterpenoids and lignans from the roots of Valeriana officinalis L.

文献类型： 外文期刊

第一作者： Wang, Peng-Cheng

作者： Wang, Peng-Cheng;Ran, Xin-Hui;Chen, Rui;Luo, Huai-Rong;Liu, Yu-Qing;Hu, Jiang-Miao;Huang, Sheng-Zhuo;Jiang, He-Zhong;Chen, Zhong-Quan;Zhou, Jun;Zhao, You-Xing;Ma, Qing-Yun;Zhao, You-Xing;Wang, Peng-Cheng

作者机构：

关键词： Acetylcholinesterase inhibition;Guaianes;Inhibitors;Kessyl 3-acetate;Sequiterpenoids;Valeriana officinalis;Valerol A

期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.408； 五年影响因子：2.351 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Two new guaiane-type sesquiterpenoids, valerol A (1) and kessyl 3-acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4α,10α-epoxyaromadendrane (7), (+)-8-hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4-O-β-D- glucopyranoside (10), and 8-hydroxypinoresinol 4′-O-β-D- glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D- and 2D-NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.

分类号： Q5

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