Phenols with anti-HIV activity from daphne acutiloba

文献类型： 外文期刊

第一作者： Huang, Sheng Zhuo

作者： Huang, Sheng Zhuo;Jiang, He Zhong;Wang, Peng Cheng;Liu, Yu Qing;Hu, Jiang Miao;Zhou, Jun;Zhao, You Xing;Ma, Qing Yun;Zhao, You Xing;Zhang, Xing Jie;Li, Xing Yao;Zheng, Yong Tang;Huang, Sheng Zhuo;Zhang, Xing Jie;Li, Xing Yao;Jiang, He Zhong;Wang, Peng Cheng

作者机构：

关键词： anti-HIV activity;Daphne acutiloba;phenols;Thymelaeceae

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

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收录情况： SCI

摘要： The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2DNMR spectroscopy as well as HR-ESI-MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIV activity with EC 50 values of 0.39 and 0.16μg/mL, respectively.

分类号： R9

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