Isolation, modulatory functions on murine B cell development and antigen-specific immune responses of BP11, a novel peptide from the chicken bursa of Fabricius

文献类型： 外文期刊

第一作者： Liu, Xiao-dong

作者： Liu, Xiao-dong;Feng, Xiu-li;Zhou, Bin;Cao, Rui-Bing;Li, Xin-feng;Chen, Pu-Yan;Ma, Zhi-Yong

作者机构：

关键词： B cell development;Bursal peptide (BP11);Immunization experiment;Immunomodulatory function

期刊名称：PEPTIDES （ 影响因子：3.75； 五年影响因子：3.389 ）

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收录情况： SCI

摘要： The bursa of Fabricius (BF) is the central humoral immune organ unique to birds which plays important roles in B lymphocyte differentiation. Here, a new bursal peptide (BP11) with the amino acid sequence DVAGKLPDNRT was identified and characterized from BF. It was proved that BP11 promoted CFU pre-B formation, and regulated B cell differentiation, including increase the percentage of immature and mature B cells in BM cells co-cultured with IL-7. BP11 also exerted immunomodulatory function on antigen-specific immune responses in BALB/c mice immunized with inactivated influence virus (AIV, H9N2 subtype) vaccine, including enhancing AIV-specific antibody and cytokine production. Furthermore, it was noteworthy that BP11 stimulated antibody productions and potentiates the Th1 and Th2-type immune responses in dose-dependent manner in chicken. These results suggested that BP11 might be highly relevant for the development of avian immune system.

分类号： Q5

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