Polysaccharides from Phellinus linteus inhibit cell growth and invasion and induce apoptosis in HepG2 human hepatocellular carcinoma cells

文献类型： 外文期刊

第一作者： Wang, Guibin

作者： Wang, Guibin;Dong, Lulu;Zhang, Yuanyuan;Zhao, Min;Ji, Yuanyuan;Xiang, Wenhua

作者机构：

关键词： antitumor;apoptosis;cell cycle;Phellinus linteus;polysaccharides

期刊名称：BIOLOGIA （ 影响因子：1.35； 五年影响因子：1.139 ）

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年卷期：

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收录情况： SCI

摘要： It has been demonstrated that the medicinal mushroom Phellinus linteus (PL), which consists mainly of polysaccharides, possesses antitumor and immunomodulatory properties in vivo and in vitro. The mechanism, however, by which PL inhibits growth and invasive behavior of HepG2 cells remains poorly understood. Here we demonstrated that PL inhibited proliferation and colony formation of HepG2 and that the growth inhibition of HepG2 cells was mediated by S-phase cell cycle arrest. PL also markedly inhibited cancer cell adhesion and invasion of the extracellular matrix. Additionally, we demonstrated that PL-induced apoptosis was associated with a reduction in B-cell lymphoma 2 levels and an increase in the release of cytochrome c. These results suggest that PL exerts a direct antitumor effect by initiating apoptosis and cell cycle blockade in HepG2 cells.

分类号： Q

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