Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus

文献类型： 外文期刊

第一作者： Meng, Chunchun

作者： Meng, Chunchun;Qiu, Xvsheng;Jin, Shiqiang;Yu, Shengqing;Chen, Hongjun;Ding, Chan;Jin, Shiqiang;Ding, Chan

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期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

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收录情况： SCI

摘要： A lentogenic Newcastle disease virus (NDV), Duck/JS/10 (JS10), was isolated from an unvaccinated duck in China. The complete genome of the virus contained 15,198 nucleotides. Based on length of the genome and a partial sequence of the F gene, the virus was classified as a class I genotype 4 NDV. The antigenicity of the virus was compared with that of NDV strain La Sota via hemagglutination inhibition (HI), virus neutralization (VN) assay and animal experiments. Our results show that JS10 generates higher HI and VN titers than La Sota against both class I and II virulent NDV strains. Experiments on animals demonstrate that virus shedding from chickens vaccinated with JS10 is significantly reduced when compared to those vaccinated with La Sota. Overall, this study strongly suggests that JS10 may qualify as a new vaccine candidate against Newcastle disease.

分类号： R37

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