Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo

文献类型： 外文期刊

第一作者： Ding, Chan

作者： Ding, Chan;Meng, Songshu;Zhou, Zhizhi;Kong, Xiangang;Liu, Huairan;Meng, Songshu;Zhou, Zhizhi;Chen, Fei;Jiang, Ke;Liu, Wenbo;Hu, Maozhi;Zhang, Xiaorong;Wu, Yantao

作者机构：

关键词： Akt;Apoptosis;Cisplatin (DDP);Mitogen-activated protein kinase (MAPK);Newcastle disease virus (NDV)

期刊名称：CANCER LETTERS （ 影响因子：8.679； 五年影响因子：8.64 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Cisplatin (DDP) is widely used in lung cancer chemotherapy. However, cisplatin resistance represents a major obstacle in effective clinical treatment. This study aims to investigate whether Newcastle disease virus (NDV) exhibits an oncolytic effect on cisplatin-resistant A549 lung cancer cells. We found that NDV induced A549/DDP cell apoptosis via the caspase pathway, particularly involving caspase-9, while the mitogen-activated protein kinase (MAPK) and Akt pathways also contributed to apoptotic induction. Furthermore, NDV displayed oncolytic effects in a mouse A549/DDP lung cancer model. Collectively, our data indicate that NDV could overcome the cisplatin resistance in lung cancer cells in vitro and in vivo.

分类号： R73

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