From cells to DNA materials

文献类型： 外文期刊

第一作者： Peng, Songming

作者： Peng, Songming;Derrien, Thomas L.;Cui, Jinhui;Xu, Chuanying;Luo, Dan;Cui, Jinhui;Xu, Chuanying

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期刊名称：MATERIALS TODAY （ 影响因子：31.041； 五年影响因子：36.768 ）

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收录情况： SCI

摘要： Materials need to be specially engineered to interface with cells; on the other hand, cells provide great inspiration for new material designs. Here, using examples mainly from our own research, we demonstrate that DNA can be used as both a genetic and generic material for various cell-related applications, including diagnostics, drug delivery, cell culture, protein production, and immuno-modulation. We envision that other cell-based materials such as RNA, proteins, polysaccharides, and lipids can be more pervasively employed in materials science and engineering. Imagine you are a cell in the body, composed of and surrounded by a number of different kinds of materials, each playing a distinct role. Inside of you, there are four primary material building blocks: nucleotides, amino acids, sugars, and fatty acids. It is from these four materials that DNA/RNA, proteins, polysaccharides, and lipids are assembled, all via enzymatic catalyses. From a materials perspective, DNA, a long linear polymer with a Young's modulus similar to Plexiglass, is an ideal genetic information storage molecule. Proteins have defined three-dimensional conformations and diverse functions which cannot be achieved with synthetic materials. In addition, polysaccharides can serve as energy storage materials while amphiphilic phospholipids can self-assemble into bilayers, forming protective boundaries for cells. Outside of you, a myriad of other molecules and materials are presented in a highly controlled fashion to maintain a homeostatic environment. For example, proper salt concentration is critical to achieve a balanced osmotic pressure. Extracellular matrix materials provide a supporting environment for cell growth and differentiation. Indeed, life as a cell is defined by the materials both inside and outside of the cell.

分类号： TB3

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