Effects of Aluminum on immune functions of cultured splenic T and B lymphocytes in rats

文献类型： 外文期刊

第一作者： She, Yue

作者： She, Yue;Wang, Nan;Xia, Shiliang;Hu, Chongwei;Li, Yanfei;Chen, Chongxiao;Zhu, Yanzhu

作者机构：

关键词： Aluminum;Immune functions;Rats;Splenic lymphocytes

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.738； 五年影响因子：3.44 ）

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收录情况： SCI

摘要： The effects of Aluminum (Al) exposure on immune functions of cultured splenic T and B lymphocytes of rats were studied. The lymphocytes were isolated from spleen of healthy male Wistar rats weighing 110-120 g. The cultured cells in RPMI-1640 medium were exposed to 0 (control group), 0.035 (low-dose group), 0.07 (medial-dose group), and 0.14 (high-dose group) mg/mL Al 3+ as aluminum trichloride (AlCl 3) in an incubator under 5% CO 2 at 37°C for 24 h. The T and B lymphocyte proliferation was measured with a tetrazolium dye colorimetric assay. The levels of interleukin (IL)-2, IL-6, and tumor necrosis factor (TNF)-α were determined by iodine [ 125I] IL-2, IL-6, and TNF-α radioimmunoassay kits, respectively. The proportions of CD3 +, CD4 +, and CD8 + T lymphocytes were measured with a flow cytometer. The results showed that the T and B lymphocyte proliferation, the levels of IL-2, IL-6, TNF-α, the proportions of CD3 + and CD4 + T lymphocytes, and the ratio of CD4 +/CD8 + T lymphocytes were lowered by Al treatments, while the proportion of CD8 + T lymphocytes was increased. These findings indicate that Al exposure can inhibit the immune functions of splenic T and B lymphocytes of rats in vitro.

分类号： Q5

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