Protective efficacy evaluation induced by recombinant protein LHD-Sj23-GST of Schistosoma japonicum emulsified with three different adjuvants

文献类型： 外文期刊

第一作者： Zhu, Z.

作者： Zhu, Z.;Fu, Z.;Zhang, M.;Han, Y.;Hong, Y.;Li, D.;Zhao, Z.;Shi, Y.;Lin, J.;Zhu, Z.;Han, Y.;Hong, Y.;Li, X.

作者机构：

关键词： adjuvant;protective immunity;recombinant LHDSj23-GST;Schistosomiasis japonica

期刊名称：PARASITE IMMUNOLOGY （ 影响因子：2.28； 五年影响因子：3.195 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： As a complement to chemotherapy and other control approaches, the development of an effective vaccine is necessary to combat Schistosomiasis japonica that remains a serious public health problem in China. In the present study, mice were vaccinated with purified recombinant protein LHD-Sj23-GST (large hydrophilic domain of 23 kDa antigen of S.similar to japonicum fused with Sj26GST) emulsified with Freunds adjuvant (FA), Montanide ISA 206 and Montanide ISA 70M and challenged with cercariae, the protective efficacy induced by the recombinant protein was evaluated, and the LHD-Sj23-GST-specific IgG and its subtypes were determined. The result revealed that a significant worm burden reduction (58.8%, 26.3% and 54.3%; P < 0.05) was obtained in mice vaccinated with LHD-Sj23-GST emulsified with three different adjuvants compared to those mice treated with respective adjuvant only. ELISA test suggested that the high-level production of LHD-Sj23-GST-specific IgG1, IgG2a and IgG3 antibodies may participate in protecting against schistosome infection.

分类号： R5

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