Protective efficacy evaluation induced by recombinant protein LHD-Sj23-GST of Schistosoma japonicum emulsified with three different adjuvants
文献类型: 外文期刊
第一作者: Zhu, Z.
作者: Zhu, Z.;Fu, Z.;Zhang, M.;Han, Y.;Hong, Y.;Li, D.;Zhao, Z.;Shi, Y.;Lin, J.;Zhu, Z.;Han, Y.;Hong, Y.;Li, X.
作者机构:
关键词: adjuvant;protective immunity;recombinant LHDSj23-GST;Schistosomiasis japonica
期刊名称:PARASITE IMMUNOLOGY ( 影响因子:2.28; 五年影响因子:3.195 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: As a complement to chemotherapy and other control approaches, the development of an effective vaccine is necessary to combat Schistosomiasis japonica that remains a serious public health problem in China. In the present study, mice were vaccinated with purified recombinant protein LHD-Sj23-GST (large hydrophilic domain of 23 kDa antigen of S.similar to japonicum fused with Sj26GST) emulsified with Freunds adjuvant (FA), Montanide ISA 206 and Montanide ISA 70M and challenged with cercariae, the protective efficacy induced by the recombinant protein was evaluated, and the LHD-Sj23-GST-specific IgG and its subtypes were determined. The result revealed that a significant worm burden reduction (58.8%, 26.3% and 54.3%; P < 0.05) was obtained in mice vaccinated with LHD-Sj23-GST emulsified with three different adjuvants compared to those mice treated with respective adjuvant only. ELISA test suggested that the high-level production of LHD-Sj23-GST-specific IgG1, IgG2a and IgG3 antibodies may participate in protecting against schistosome infection.
分类号: R5
- 相关文献
作者其他论文 更多>>
-
Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation
作者:Zhang, X.;Li, X.;Wang, X.;Li, J.;An, Y.;Li, L.;Zhang, P.;Dong, X.;Ze, X.
关键词:
-
Oxidative stress response in tilapia (GIFT, Oreochromis niloticus) liver after subacute exposure to subacute 1,3-dibromo-5,5-dimethylhydantoin (DBDMH)
作者:Zheng, Y.;Xu, G.;Zheng, Y.;Sun, B.;Zhao, Z.;Barry, K.;Xu, G.
关键词:Disinfectant; Antioxidative defense; Tilapia; Residual; Biomarker
-
Morpho-molecular characterization and pathogenicity of fungi associated with sweet cherry (Prunus avium) trunk diseases in China
作者:Zhang, W.;Chen, P.;Zhou, Y.;Ji, S.;Li, X.;Abeywickrama, P. D.;Yan, J.;Zhou, Y.;Hyde, K. D.;Zhou, Y.;Hyde, K. D.;Hyde, K. D.;Hyde, K. D.
关键词:Fungal taxonomy; Fusarium oxysporum species complex; Koch's postulates; Monilinia; Trunk diseases
-
Steinernema tarimense n. sp. (Rhabditida: Steinernematidae), a new entomopathogenic nematode from Tarim Basin, Xinjiang, China
作者:Zhan, F.;Zhan, F.;Yang, R.;Bao, H.;Zhang, S.;Zhang, X.;Shi, Y.;Tian, C.;Li, H.;Tomalak, M.;Puza, V.;Guo, W.
关键词:morphological description; phylogenetic systematics;
Populus euphratica forest;Steinernema species; Tarim Basin -
DIFFERENCES IN NUTRIENT FUNCTIONAL COMPOSITION AMONG DIFFERENT TYPES OF GRAINS IN BARLEY (HORDEUM VULGARE L.) RECOMBINANT INBRED LINES
作者:Yang, X.;Ahmed, H. G. M. D.;Pu, X.;Li, X.;Yang, L.;Yang, G.;Guan, X.;Tian, J.;Zeng, Y.;Ahmed, H. G. M. D.;Yang, L.;Guan, X.;Tian, J.;Iqbal, R.;Iqbal, R.;Akram, M. I.;Alwahibi, M.;Elshikh, M. S.
关键词:barley; anthocyanin; amylose; beta-glucan; protein; correlation
-
Culture Optimization of Endophytic and Rhizosphere Bacteria and Exploration of Antifungal Substances
作者:Sheng, Y.;Zhang, G.;Sheng, Y.;Li, X.;Yang, H.;Chu, M.;Wang, N.;Bao, H.;Zhan, F.;Yang, R.;Lou, K.;Shi, Y.;Sheng, Y.;Li, X.;Yang, H.;Chu, M.;Niu, X.;Wang, N.;Bao, H.;Zhan, F.;Yang, R.;Lou, K.;Shi, Y.;Li, X.;Niu, X.;Wang, N.;Shi, Y.;Niu, X.
关键词:culture optimization; antifungal substances; verticillium dahlia; endophytic bacteria; rhizosphere bacteria
-
High-throughput proximal ground crop phenotyping systems - A comprehensive review
作者:Rui, Z.;Zhang, Z.;Zhang, M.;Azizi, A.;Li, H.;Wang, M.;Rui, Z.;Zhang, Z.;Zhang, M.;Azizi, A.;Li, H.;Wang, M.;Igathinathane, C.;Cen, H.;Vougioukas, S.;Zhang, J.;Jiang, Y.;Jiao, X.;Ampatzidis, Y.;Oladele, O. I.;Ghasemi-Varnamkhasti, M.;Radi, Radi
关键词:High-throughput phenotyping; Phenotyping platform; Sensing technology; Data processing; Precision agriculture