Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs
文献类型: 外文期刊
第一作者: Kong, Dongni
作者: Kong, Dongni;Wen, Zhiyuan;Su, Hua;Ge, Jinying;Chen, Weiye;Wang, Xijun;Wu, Chao;Chen, Hualan;Bu, Zhigao;Kong, Dongni;Wen, Zhiyuan;Su, Hua;Ge, Jinying;Chen, Weiye;Wang, Xijun;Wu, Chao;Chen, Hualan;Bu, Zhigao;Kong, Dongni;Yang, Chinglai
作者机构:
关键词: Glycoprotein;Nipah encephalitis virus;Recombinant Newcastle disease virus;Vaccine
期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )
ISSN:
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收录情况: SCI
摘要: Nipah virus (NiV), a member of the Paramyxoviridae family, causes deadly encephalitis in humans and huge economic losses to the pig industry. Here, we generated recombinant avirulent Newcastle disease virus (NDV) LaSota strains expressing the NiV G and F proteins respectively (designated as rLa-NiVG and rLa-NiVF), and evaluated their immunogenicity in mice and pigs. Both rLa-NiVG and rLa-NiVF displayed growth properties similar to those of LaSota virus in chicken eggs. Co-infection of rLa-NiVG and rLa-NiVF caused marked syncytia formation, while intracerebral co-inoculation of these viruses in mice showed they were safe in at least one mammalian species. Animal immunization studies showed rLa-NiVG and rLa-NiVF induced NiV neutralizing antibody responses in mice and pigs, and F protein-specific CD8+ T cell responses in mice. Most importantly, rLa-NiVG and rLa-NiVF administered alone or together, induced a long-lasting neutralizing antibody response in pigs. Recombinant rLa-NiVG/F thus appear to be promising NiV vaccine candidates for pigs and potentially humans.
分类号: R37
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