Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses

文献类型： 外文期刊

第一作者： Zhao, Dongming

作者： Zhao, Dongming;Liang, Libin;Li, Yanbing;Liu, Liling;Guan, Yuntao;Jiang, Yongping;Chen, Hualan

作者机构：

关键词： H5N1 viruses;Microbiology;Mouse;Proteomic analysis

期刊名称：PROTEOMICS （ 影响因子：3.984； 五年影响因子：3.831 ）

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收录情况： SCI

摘要： The virulence of influenza virus is determined by viral and host factors. Data on the genetic basis of the virulence of H5N1 influenza viruses have increased over the past decade; however, the contributions of host factors to the outcomes of H5N1 infection remain largely unknown. Here, we tested two chicken H5N1 viruses in mice and found that A/chicken/VN1214/2007 was nonlethal in mice and only replicated in the lung, whereas A/chicken/VN1180/2006 was highly lethal and replicated systemically in mice. To investigate the host response against these two different virus infections, we performed proteomic analysis by using 2D DIGE on the lung tissues of mice collected on days 1 and 3 postinoculation with different viruses or PBS as a control. Thirty-nine differentially expressed (DE) proteins related to "immune and stimulus response," "macromolecular biosynthesis and metabolism," and "cellular component and cytoskeleton" were identified in the virus-inoculated groups. Moreover, 13 DE proteins were identified between the two virus-inoculated groups, implying that these proteins may play important roles in the different outcomes of infection with these two viruses. Our data provide important information regarding the host response to mild and lethal H5N1 influenza virus infection.

分类号： Q5

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