Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation

文献类型: 外文期刊

第一作者: Shi, Liqiao

作者: Shi, Liqiao;Hui, Rui;Wei, Yanhong;Liang, Ying;Yang, Ziwen;Ke, Shaoyong

作者机构:

关键词: Anthranilic diamides;Antitumor activity;Aryl-isoxazoline;Synthesis

期刊名称:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ( 影响因子:6.514; 五年影响因子:6.099 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by 1H NMR, 13C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.

分类号: R9

  • 相关文献

[1]Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents. Ke, Shaoyong,Shi, Liqiao,Yang, Ziwen.

[2]Design, Synthesis and Bioactivity of N-Glycosyl-N '-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives. Cui, Zining,Nishida, Yoshihiro,Su, Hang,Jiang, Jiazhen,Yang, Xinling,Cui, Zining. 2014

[3]Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety. Cui, Zining,Dohi, Hirofumi,Nishida, Yoshihiro,Cui, Zining,Yang, Xinling,Shi, Yanxia,Uzawa, Hirotaka,Cui, Jingrong. 2011

[4]Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan. Cui, Zi-Ning,Ling, Yun,Yang, Xin-Ling,Shi, Yan-Xia,Li, Bao-Ju,Cui, Jing-Rong. 2012

[5]Synthesis and in vitro antitumor activity of (1E, 4E)-1-aryl-5-(2-(( quinazolin-4-yl) oxy) phenyl)-1,4-pentadien-3-one derivatives. Luo, Hui,Xie, Pu,Yang, Shengjie,Hong, Da,Luo, Hui,Yang, Shengjie,Xue, Wei,Luo, Hui,Yang, Shengjie,Xue, Wei. 2017

[6]Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan. Li, Xinghai,Cui, Zining,Nishida, Yoshihiro,Cui, Zining. 2014

[7]Synthesis of Novel Steroid Derivatives Derived from Dehydroepiandrosterone as Potential Anticancer Agents. Ke, Shaoyong,Shi, Liqiao,Yang, Qingyu,Yang, Ziwen,Wei, Yanhong,Yang, Ziwen. 2013

[8]First report of field resistance to cyantraniliprole, a new anthranilic diamide insecticide, on Bemisia tabaci MED in China. Wang Ran,Luo Chen,Wang Jin-da,Che Wu-nan. 2018

[9]Synthesis, Crystal Structure and Biological Activity of Novel Anthranilic Diamides Containing 1,2,3-Thiadiazole. Dong, Wei-Li,Xu, Jun-Ying,Liu, Xing-Hai,Li, Zheng-Ming,Li, Bao-Ju,Shi, Yan-Xia. 2008

[10]Effect of nutritional and environmental conditions on the production of exo-polysaccharide of Agaricus brasiliensis by submerged fermentation and its antitumor activity. Fan, Leifa,Soccol, Andrea Thomaz,Pandey, Ashok,Soccol, Carlos Ricardo. 2007

[11]Optimization of Enzyme-assisted Extraction of Antitumor Polysaccharides from Hericium erinaceus mycelia. Qin, Yi,Zhang, Zuofa,Song, Tingting,Lv, Guoying.

[12]Antioxidant and Cytotoxic Activities of Ethanolic Extracts and Isolated Fractions of Species of the Genus Phellinus Quel. (Aphyllophoromycetideae). Yang, Yan,Hu, Jinxia,Liu, Yanfang,Feng, Na,Chen, Hui,Tang, Qingjiu,Zhang, Jingsong,Ye, LinBin. 2011

[13]A novel antibiotic produced by streptomyces noursei Da07210. Wu, Xiaopeng,Huang, Huiqin,Sun, Qianguang,Peng, Jie,Zhu, Jun,Bao, Shixiang,Chen, Guangying. 2009

[14]Chemical Characterization of a Procyanidin-Rich Extract from Sorghum Bran and Its Effect on Oxidative Stress and Tumor Inhibition in Vivo. Wu, Li,Huang, Zhaohui,Qin, Peiyou,Yao, Yang,Ren, Guixing,Huang, Zhaohui,Meng, Xianjun,Zou, Jianqiu,Zhu, Kai.

[15]Immunoregulatory and antitumor activity of schizophyllan under ultrasonic treatment. Zhong, Kui,Tong, Litao,Liu, Liya,Zhou, Xianrong,Liu, Xingxun,Zhang, Qi,Zhou, Sumei,Zhong, Kui,Tong, Litao,Liu, Liya,Zhou, Xianrong,Liu, Xingxun,Zhang, Qi,Zhou, Sumei.

[16]Synthesis and biological activities of 2-oxocycloalkylsulfonamides. Yang, Xinling,Liang, Xiaomei,Kai, Zhenpeng,Yuan, Dekai,Zhang, Jianjun,Ling, Yun,Chen, Fuheng,Wang, Daoquan,Yuan, Huizu,Qi, Shuhua,Wang, Ruiqing,Ran, Fuxiang. 2008

[17]Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety. He, Haifeng,Wang, Xiaoyan,He, Hongwu,Shi, Liqiao,Yin, Wenyan,Yang, Ziwen,Liang, Ying. 2016

[18]Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth. Jia, Wei,Bai, Yan-Yan,Zhang, Zhong,Feng, Na,Feng, Jie,Yan, Meng-Qiu,Zhu, Li-Na,Zhang, Jing-Song,Fan, Hua,Bai, Yan-Yan,Jia, Xin-Cheng,Wang, Ming-Dao,Fan, Hua.

[19]Structural elucidation and in vitro antitumor activity of a novel oligosaccharide from Bombyx batryticatus. Jiang, Xue,Chen, Yajie,Cui, Zhenteng,Shi, Liangen,Zhang, Zuofa.

[20]Extraction optimization and biological properties of a polysaccharide isolated from Gleoestereum incarnatum. Zhang, Zuo-fa,Lv, Guo-ying,Cheng, Jian-hui,Fan, Lei-fa,Jiang, Xue.

作者其他论文 更多>>