Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation
文献类型: 外文期刊
第一作者: Shi, Liqiao
作者: Shi, Liqiao;Hui, Rui;Wei, Yanhong;Liang, Ying;Yang, Ziwen;Ke, Shaoyong
作者机构:
关键词: Anthranilic diamides;Antitumor activity;Aryl-isoxazoline;Synthesis
期刊名称:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ( 影响因子:6.514; 五年影响因子:6.099 )
ISSN:
年卷期:
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收录情况: SCI
摘要: A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by 1H NMR, 13C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.
分类号: R9
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