Heterocycle-functional gramine analogues: Solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation

文献类型: 外文期刊

第一作者: Ke, Shaoyong

作者: Ke, Shaoyong;Shi, Liqiao;Yang, Qingyu;Liang, Ying;Yang, Ziwen;Cao, Xiufang

作者机构:

关键词: Cell proliferation;Gramine analogues;Inhibition activity;Synthesis

期刊名称:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ( 影响因子:6.514; 五年影响因子:6.099 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: A series of novel gramine analogues were designed and synthesized via a convenient three-component reaction, and which were evaluated for their inhibition activities against cell proliferation. Their structures were confirmed by satisfactory spectra analyses mainly including 1H NMR, and ESI-MS analyses. The preliminary assays indicated that some of the newly synthesized compounds displayed significantly good inhibition activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) cell lines compared with the control 5-Fluorouracil (5-FU), which might be developed as novel lead scaffold for potential anticancer agents.

分类号: R9

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