Synthesis of aspirin eugenol ester and its biological activity

文献类型: 外文期刊

第一作者: Li, Jian-yong

作者: Li, Jian-yong;Yu, Yuan-guang;Wang, Qi-wen;Zhang, Ji-yu;Yang, Ya-jun;Li, Bing;Zhou, Xu-zheng;Niu, Jian-rong;Wei, Xiao-juan;Liu, Xi-wang;Liu, Zhi-qi

作者机构:

关键词: Aspirin eugenol ester (AEE);Synthesis;Toxicity;Anti-inflammation;Analgesic and antipyretic effects

期刊名称:MEDICINAL CHEMISTRY RESEARCH ( 影响因子:1.965; 五年影响因子:1.98 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Aspirin, as starting precursor, was reacted with SOC12 to generate acyl chloride compound via esterifying eugenol to aspirin eugenol ester (AEE) with a yield of 65%. Tests of AEE for acute toxicity, anti-inflammatory, analgesic, and antipyretic effects were carried out in mice and rats. The results showed that toxicity of AEE was significantly reduced, about 50 and 3.7 times lower than aspirin and eugenol, respectively. Its strength of anti-inflammation, analgesia, and antipyresis was similar as aspirin and eugenol, but the effects lasted longer.

分类号: R9

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