Molecular characteristics of the porcine TIMD4 gene and its association analysis

文献类型： 外文期刊

第一作者： Yuan, Jing

作者： Yuan, Jing;Tang, Zhong-Lin;Yang, Shulin;Li, Kui;Cao, Ji-Yue

作者机构：

关键词： Association analysis;Expression pattern;Porcine;Subcellular localization;TIMD4

期刊名称：BIOCHEMICAL GENETICS （ 影响因子：1.89； 五年影响因子：1.959 ）

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年卷期：

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收录情况： SCI

摘要： As a member of the T cell immunoglobulin domain and mucin domain (TIM) gene family, TIMD4 plays an important role in the immune response. To understand its function more precisely, we isolated it and analyzed its subcellular localization, expression pattern, and associations. The porcine TIMD4 gene included nine exons and eight introns with an open reading frame of 1086 bp encoding 361 amino acids. It had relatively high levels in liver, lymph, and spleen. The fusion protein was localized mainly in the cytoplasm of pig kidney cells (PK15). The promoter region contained a TATA box and GATA3 consensus sites. A single nucleotide polymorphism was identified in intron 3 of the porcine TIMD4 gene, and analysis indicated that it had significant associations with the 17-day red blood cell count (p = 0.0106), hemoglobin (p = 0.0149), and hematocrit (p = 0.0063) and with 32-day hemoglobin (p = 0.0140).

分类号： Q3

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