Isolation of a new meroterpene and inhibitors of nitric oxide production from Psoralea corylifolia fruits guided by TLC bioautography

文献类型： 外文期刊

第一作者： Xiao, Guodong

作者： Xiao, Guodong;Li, Xiangkun;Wu, Tao;Zhang, Tong;Cheng, Zhihong;Tang, Qingjiu

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关键词： Meroterpene;Psoralea corylifolia;TLC bioautography;NO production

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

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收录情况： SCI

摘要： A new meroterpene, psoracorylifol F (1), was isolated from Psoralea corylifolia fruits, along with two known meroterpenes (2 and 3), guided by TLC bioautography against O-2 center dot(-) radicals. The structure of 1 was elucidated by means of NMR, HRESIMS, and X-ray crystallographic analysis. All the three metroterpenes possessed potential inhibitory activity against LPS-induced NO production in RAW 264.7 cells with IC50 values ranging from 7.71 to 27.63 mu M

分类号： S759.82

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