Expression pattern of L-FABP gene in different tissues and its regulation of fat metabolism-related genes in duck

文献类型： 外文期刊

第一作者： He, Jun

作者： He, Jun;Tian, Yong;Li, Jinjun;Shen, Junda;Tao, Zhengrong;Lu, Lizhi;He, Jun;Fu, Yan;Niu, Dong

作者机构：

关键词： Duck;L-FABP;SiRNA;Fat metabolism-related gene;Oleic acid

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Liver fatty acid binding protein (L-FABP) is a member of intracellular lipid-binding proteins responsible for the transportation of fatty acids. The expression pattern of duck L-FABP mRNA was examined in this study by quantitative RT-PCR. The resultsshowed that duck L-FABP gene was expressed in many tissues, including heart, lung, kidney, muscle, ovary, brain, intestine, stomach and adipocyte tissues, and highly expressed in liver. Several lipid metabolism-related genes were selected to detect the regulation of L-FABP in duck. The expression of L-FABP and lipoprotein lipase was promoted by oleic acid. The L-FABP knockdown decreased the expression levels of peroxisome proliferator-activated receptor alpha (PPAR alpha), fatty acid synthase and lipoprotein lipase by 61.1, 42.3 and 53.7 %, respectively (P < 0.05), but had no influences on the mRNA levels of PPAR gamma and leptin receptor. L-FABP might function through the PPAR alpha to regulate the fat metabolism-related gene expression and play important roles in lipid metabolism in duck hepatocytes.

分类号： Q7

  • 相关文献

[1]Differential expression of L-FABP and L-BABP between fat and lean chickens. Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Wang, Q.,Li, H.,Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Li, H.,Wang, Q.. 2013

[2]Role of a liver fatty acid-binding protein gene in lipid metabolism in chicken hepatocytes. Gao, G. L.,Na, W.,Wang, Y. X.,Zhang, H. F.,Li, H.,Wang, Q. G.,Gao, G. L.,Na, W.,Wang, Y. X.,Zhang, H. F.,Li, H.,Wang, Q. G.,Gao, G. L.,Na, W.,Wang, Y. X.,Zhang, H. F.,Li, H.,Wang, Q. G.,Gao, G. L.,Wang, Q. G.. 2015

[3]Association of T1740C polymorphism of L-FABP with meat quality traits in Junmu No. 1 white swine. Zhang, Y. H.,Dai, L. S.,Ma, T. H.,Li, F. J.,Liu, D. F.,Gao, Y.,Zhang, J. B.,Zhang, Y. H.,Guo, J.,Sun, B. X.,Gao, Y.,Zhang, J. B.,Wang, S. Z.,Zhang, S. M.. 2013

[4]Identification of SNPs of the L-BABP and L-FABP and their Association with Growth and Body Composition Traits in Chicken. Zhao, Yufang,Rong, Enguang,Wang, Shouzhi,Zhang, Hui,Leng, Li,Wang, Yuxiang,Wang, Qigui,Li, Hui,Zhao, Yufang,Rong, Enguang,Wang, Shouzhi,Zhang, Hui,Leng, Li,Wang, Yuxiang,Wang, Qigui,Li, Hui,Zhao, Yufang,Rong, Enguang,Wang, Shouzhi,Zhang, Hui,Leng, Li,Wang, Yuxiang,Li, Hui,Wang, Qigui.

[5]Microbial lipid production by the oleaginous yeast Cryptococcus curvatus O3 grown in fed-batch culture. Zhang, Jie,Li, Yan,Xu, Hai-Peng,Zhao, Bao-Feng,Chen, Lei,Zhang, Xiao-Dong,Zhang, Jie,Fang, Xu,Zhu, Xiao-Ling. 2011

[6]Screening and Identification of Differentially Expressed Genes in Goose Hepatocytes Exposed to Free Fatty Acid. Pan, Zhixiong,Wang, Jiwen,Kang, Bo,Han, Chunchun,Tang, Hui,Li, Liang,Xu, Feng,Zhou, Zehui,Lv, Jia,Lu, Lizhi. 2010

[7]Identification of QTLs associated with oil content and mapping FAD2 genes and their relative contribution to oil quality in peanut (Arachis hypogaea L.). Pandey, Manish K.,Qiao, Lixian,Feng, Suping,Khera, Pawan,Wang, Hui,Guo, Baozhu,Pandey, Manish K.,Khera, Pawan,Varshney, Rajeev K.,Pandey, Manish K.,Qiao, Lixian,Feng, Suping,Khera, Pawan,Wang, Hui,Culbreath, Albert K.,Guo, Baozhu,Wang, Ming Li,Tonnis, Brandon,Barkley, Noelle A.,Qiao, Lixian,Feng, Suping,Wang, Hui,Wang, Jianping,Holbrook, C. Corley. 2014

[8]Cs-substituted H3PW12O40 on Palygorskite Clay for Esterification of Oleic Acid with Ethanol. Zhang, L. X.,Jin, Q. Z.,Shan, L.,Liu, Y. F.,Huang, J. H.,Wang, X. G.,Zhang, L. X.. 2012

[9]Comparison of the Delta(12) fatty acid desaturase gene between high-oleic and normal-oleic peanut genotypes. Yu, Shanlin,Pan, Lijuan,Zhang, Hongsheng,Pan, Lijuan,Yang, Qingli,Min, Ping,Ren, Zengkai. 2008

[10]A novel Ganoderma lucidum G0119 fermentation strategy for enhanced triterpenes production by statistical process optimization and addition of oleic acid. Feng, Jie,Zhang, Jing-Song,Feng, Na,Yan, Meng-Qiu,Yang, Yan,Jia, Wei,Lin, Chi-Chung,Feng, Jie,Zhang, Jing-Song,Feng, Na,Yan, Meng-Qiu,Yang, Yan,Jia, Wei,Lin, Chi-Chung,Feng, Jie,Zhang, Jing-Song,Feng, Na,Yan, Meng-Qiu,Yang, Yan,Jia, Wei,Lin, Chi-Chung.

[11]Synthesis and Characterization of Superparamagnetic Fe3O4 Nanoparticles Modified with Oleic Acid. Wang, Fei,Yin, Chan,Wei, Xiaoyi,Wang, Qinghuang,Cui, Lihong,Wang, Yihong,Li, Te,Li, Jihua,Wang, Qinghuang,Li, Jihua,Wang, Yihong. 2014

[12]Semi-rational engineering of cytochrome CYP153A from Marinobacter aquaeolei for improved omega-hydroxylation activity towards oleic acid. Duan, Yan,Ba, Lina,Gao, Jianwei,Gao, Xianxing,Lin, Zhanglin,Ba, Lina,Zhu, Dunming,de Jong, Rene M.,Mink, Daniel,Kaluzna, Iwona.

[13]The Synthesis of Methyl Oleate Catalyzed by Phosphotungstic Acid Immobilized on the Functionalized Palygorskite. Zhang, L. X.,Jin, Q. Z.,Huang, J. H.,Liu, Y. F.,Shan, L.,Wang, X. G.,Zhang, L. X.. 2012

[14]RNAi knockdown of fatty acid elongase1 alters fatty acid composition in Brassica napus. Shi, Jianghua,Lang, Chunxiu,Wu, Xuelong,Liu, Renhu,Zheng, Tao,Chen, Jinqing,Wu, Guanting,Zhang, Dongqing.

[15]Analysis of genetic and genotype x environment interaction effects from embryo, cytoplasm and maternal plant for oleic acid content of Brassica napus L.. Zhang, HZ,Shi, CH,Wu, JG,Ren, YL,Li, CT,Zhang, DQ,Zhang, YF.

[16]Effects of Different Oils on the Fatty Acid Profiles of Culture Medium and Ruminal Microorganisms in vitro. Wang, M. Z.,Wang, H. R.,Yu, L. H.,Bu, D. P.,Wang, J. Q.. 2012

[17]Chemical composition of diaspores of the myrmecochorous plant Stemona tuberosa Lour. Chen, Gao,Sun, Wei-Bang,Chen, Gao,Sun, Wei-Bang,Huang, Sheng-Zhuo,Chen, Si-Chong,Chen, Yu-Han,Liu, Xu.

[18]Depressed expression of FAE1 and FAD2 genes modifies fatty acid profiles and storage compounds accumulation in Brassica napus seeds. Shi, Jianghua,Lang, Chunxiu,Wang, Fulin,Wu, Xuelong,Liu, Renhu,Zheng, Tao,Chen, Jinqing,Wu, Guanting,Zhang, Dongqing.

[19]Interference of porcine reproductive and respiratory syndrome virus replication on MARC-145 cells using DNA-based short interfering RNAs. He, Yun-xia,Hua, Rong-hong,Zhou, Yan-jun,Qiu, Hua-ji,Tong, Guang-zhi. 2007

[20]Expression of IL-13R alpha 2 in liver cancer cells and its effect on targeted therapy of liver cancer. Hou, Lingling,Du, Juan,Liu, Yanfeng,Sun, Weimin,Zheng, Yanpeng,Zhang, Lishu,Hu, Honggang,Dai, Xinxian,Hong, Tao,Wang, Jianwei,Guan, Weijun,Ma, Yuehui. 2010

作者其他论文 更多>>

微信小程序