Cytotoxicity evaluation of coumarin derivatives containing 4-bromophenyl or anthracene moieties

文献类型： 外文期刊

第一作者： Zhang, Hui

作者： Zhang, Hui;Zhao, Ming;Yu, Tianzhi;Fan, Duowang;Zhao, Ming;Zhao, Yuling;Zhang, Shidong

作者机构：

关键词： 4-Bromophenyl;Anthracene;Coumarin;Cytotoxic activity;SRB

期刊名称：RESEARCH ON CHEMICAL INTERMEDIATES （ 影响因子：2.914； 五年影响因子：2.32 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The cytotoxic properties of four synthesized coumarin derivatives containing 4-bromophenyl or anthracene moieties against the human hepatocellular carcinoma cell lines (HepG-2) were investigated in vitro by use of the sulforhodamine B (SRB) assay. The four coumarin derivatives are 3-(4-bromophenyl)-benzo[5,6]coumarin (1a), 3-(4-bromophenyl)-7-(N,N- diethylamino)coumarin (1b), 3-(4-(anthracen-10-yl)phenyl)-benzo[5,6]coumarin (2a), and 3-(4-(anthracen-10-yl)phenyl)-7-(N,N-diethylamino)coumarin (2b). The preliminary results indicate that 1a, 2a, and 2b have significant cytotoxicity against HepG-2 whereas 1b has a growth-promotion effect.

分类号： O62

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