Role of nitric oxide in the control of the gastric motility within the nucleus ambiguus of rats

文献类型： 外文期刊

第一作者： Sun, H-Z

作者： Sun, H-Z;Zhao, S-Z;Ai, H-B

作者机构：

关键词： Gastric motility;Hexamethonium bromide;Nitric oxide;Nucleus ambiguus;Sodium nitroprusside;Vagotomy

期刊名称：JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY （ 影响因子：3.011； 五年影响因子：2.927 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： This study aims to investigate whether exogenous nitric oxide (NO) plays a role in controlling gastric motility within the nucleus ambiguus (NA). Experiments were performed on male Wistar rats anaesthetized with chloral hydrate. Alatex balloon, connected to a pressure transducer, was inserted into the pylorus through the fundus for continuous recording of the change of gastric smooth muscle contractile curves. Microinjection of the NO-donor sodium nitroprusside (SNP; 5 nmol) or L-arginine (L-Arg; 5 nmol) into the NA significantly inhibited gastric motility, whereas the treatment of NOsynthase inhibitor N-nitro-L-arginine methylester (L-NAME) increased gastric motility remarkably. The negative effect of SNP or L-Arg on gastric motility was abolished by bilateral subdiaphragmatic vagotomy as well as by intravenous injection of ganglionic blocker, hexamethonium bromide (Hb). These results demonstrated that NO inhibited gastric motility by activating the cholinergic preganglionic neurons in the NA and through the mediation of vagus nerves.

分类号： R9

  • 相关文献

[1]Microinjection of L-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor - nitric oxide pathway. Sun, Hong-Zhao,Zhao, Shu-Zhen,Ai, Hong-Bin.

[2]Effects of Abscisic Acid and Nitric Oxide on Chilling Resistance and Activation of the Antioxidant System in Walnut Shoots In Vitro. Dong, Ningguang,Qi, Jianxun,Chen, Yonghao,Hao, Yanbin,Li, Yuanfa.

[3]Drought-induced proline accumulation is uninvolved with increased nitric oxide, which alleviates drought stress by decreasing transpiration in rice. Xiong, Jie,Fu, Guanfu,Yang, Yongjie,Tao, Longxing,Zhang, Long,Zhu, Cheng.

[4]Exogenous sodium nitroprusside treatment of broccoli florets extends shelf life, enhances antioxidant enzyme activity, and inhibits chlorophyll-degradation. Shi, Junyan,Gao, Lipu,Zuo, Jinhua,Wang, Qing,Wang, Qian,Fan, Linlin,Shi, Junyan,Gao, Lipu,Zuo, Jinhua,Wang, Qing,Wang, Qian,Fan, Linlin.

[5]Nitric oxide effect on root architecture development in Malus seedlings. Yang, H. Q.,Gao, H. J..

[6]Label-free quantitative proteomics analysis of cotton leaf response to nitric oxide. Yanyan Meng,Feng Liu,Chaoyou Pang,Shuli Fan,Meizhen Song,Dan Wang,Weihua Li,Shuxun Yu.

[7]Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin. Funaro, Antonietta,Wu, Xian,Song, Mingyue,Zheng, Jinkai,Guo, Shanshan,Rakariyatham, Kanyasiri,Xiao, Hang,Funaro, Antonietta,Rodriguez-Estrada, Maria Teresa,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan. 2016

[8]Hydrogen-induced osmotic tolerance is associated with nitric oxide-mediated proline accumulation and reestablishment of redox balance in alfalfa seedlings. Su, Jiuchang,Zhang, Yihua,Nie, Yang,Cheng, Dan,Shen, Wenbiao,Wang, Ren,Hu, Huali,Chen, Jun,Zhang, Jiaofei,Du, Yuanwei. 2018

[9]Exogenously Applied Nitric Oxide Enhances the Drought Tolerance in Hulless Barley. Zhong, Yan,Wu, Xiaoli. 2015

[10]Nitric oxide suppresses aluminum-induced programmed cell death in peanut (Arachis hypoganea L.) root tips by improving mitochondrial physiological properties. Huang, Wenjing,Oo, Thet Lwin,Gu, Minghua,Zhan, Jie,Wang, Aiqin,He, Long-Fei,He, Huyi,He, Long-Fei. 2018

[11]Effects of nitric oxide treatment on the cell wall softening related enzymes and several hormones of papaya fruit during storage. Guo, Qin,Chen, Weixin,Li, Xueping,Guo, Qin,Zhang, Yuli,Wang, Jide,Wu, Bin. 2014

[12]Nitrite oxide and inducible nitric oxide synthase were regulated by polysaccharides isolated from Glycyrrhiza uralensis Fisch. Cheng, Anwei,Jin, Zhengyu,Xu, Xueming,Wan, Fachun,Wang, Jiaqi. 2008

[13]hsdS, Belonging to the Type I Restriction-Modification System, Contributes to the Streptococcus suis Serotype 2 Survival Ability in Phagocytes. Xu, Bin,Zhang, Ping,Li, Weiyi,Liu, Rui,Tang, Jinsheng,Fan, Hongjie,Zhang, Ping,Fan, Hongjie. 2017

[14]Picomol Assay of Nitric Oxide Screening in Biological Samples by Derivatization Combined with High-throughput Microplate Format. Zhang, Xiaoling,Yang, Qiao. 2013

[15]Molecular regulation of terpenoid indole alkaloids pathway in the medicinal plant, Catharanthus roseus. Zhou, Mei-Liang,Wu, Yan-Min,Tang, Yi-Xiong,Zhou, Mei-Liang,Shao, Ji-Rong,Hou, Hong-Li,Zhu, Xue-Mei. 2010

[16]Nitric oxide synthase-dependent nitric oxide production enhances chilling tolerance of walnut shoots in vitro via involvement chlorophyll fluorescence and other physiological parameter levels. Dong, Ningguang,Qi, Jianxun,Chen, Yonghao,Hao, Yanbin,Li, Yuanfa. 2018

[17]Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo. Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang. 2017

[18]Exogenous nitric oxide enhances cadmium tolerance of rice by increasing pectin and hemicellulose contents in root cell wall. Xiong, Jie,An, Lingyao,Lu, Han,Zhu, Cheng,Xiong, Jie.

[19]Arginine affects appetite via nitric oxide in ducks. Wang, C.,Hou, S. S.,Huang, W.,Rong, G. H.,Xie, M.,Wang, C.,Xu, T. S..

[20]Tomato-Pseudomonas syringae interactions under elevated CO2 concentration: the role of stomata. Li, Xin,Sun, Zenghui,Shao, Shujun,Zhang, Shuai,Ahammed, Golam Jalal,Zhang, Guanqun,Jiang, Yuping,Zhou, Jie,Xia, Xiaojian,Zhou, Yanhong,Yu, Jingquan,Shi, Kai,Li, Xin,Jiang, Yuping,Yu, Jingquan,Shi, Kai.

作者其他论文 更多>>

微信小程序