Age- and sex-associated differences in the glycopatterns of human salivary glycoproteins and their roles against influenza A virus

文献类型： 外文期刊

第一作者： Qin, Yannan

作者： Qin, Yannan;Zhong, Yaogang;Zhu, Minzhi;Dang, Liuyi;Yu, Hanjie;Chen, Zhuo;Chen, Wentian;Li, Zheng;Wang, Xiurong;Zhang, Hua

作者机构：

关键词： age;glycopattern;influenza A virus;lectin microarrays;saliva;saliva microarrays;sex

期刊名称：JOURNAL OF PROTEOME RESEARCH （ 影响因子：4.466； 五年影响因子：4.352 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Recent studies have elucidated that expression of certain glycoproteins in human saliva is increased or decreased according to age; meanwhile, human saliva may inhibit viral infection and prevent viral transmission. However, little is known about the age- and sex-associated differences in the glycopatterns of human salivary glycoproteins and their significant roles against influenza A virus (IVA). Here, we investigate the glycopatterns of human salivary glycoproteins with 180 healthy saliva samples divided into six age/sex groups using lectin microarrays and fabricate saliva microarrays to validate the terminal carbohydrate moieties of glycoproteins in individual saliva samples. Furthermore, we assess the inhibiting and neutralizing activity of saliva against two strains of influenza A (H9N2) virus. We find that seven lectins (e.g., MAL-II and SNA) show significant age differences in both females and males, and seven lectins (e.g., WFA and STL) show significant sex differences in children, adults and elderly people. Interestingly, we observe that elderly individuals have strongest resistance to IVA partly by presenting more terminal α2-3/6-linked sialic acid residues in their saliva, which bind with the influenza viral hemagglutinations. We conclude that age- and sex-associated differences in the glycopatterns of human salivary glycoproteins may provide pivotal information to help understand some age related diseases and physiological phenomena.

分类号： Q7

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