Targeting cellular apoptotic pathway with peptides from marine organisms

文献类型： 外文期刊

第一作者： Zheng, Lanhong

作者： Zheng, Lanhong;Zheng, Yuan;Sheng, Jun;Ji, Xiaofeng;Sun, Mi;Lin, Xiukun;Wu, Ning;Liu, Ming

作者机构：

关键词： Apoptosis;Marine organisms;Peptides

期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER （ 影响因子：10.68； 五年影响因子：10.193 ）

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收录情况： SCI

摘要： Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties.

分类号： Q5

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