Enantioselective separation and transformation of metalaxyl and its major metabolite metalaxyl acid in tomato and cucumber

文献类型： 外文期刊

第一作者： Dong, Fengshou

作者： Dong, Fengshou;Liu, Xingang;Xu, Jun;Chen, Xiu;Han, Yongtao;Cheng, Youpu;Zheng, Yongquan;Jian, Qiu

作者机构：

关键词： Metalaxyl;Metabolite;Enantioselectivity;Transformation;Degradation;LC-MS/MS

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Many studies have shown the enantioselective transformation of metalaxyl in soil and animals, but little is known about the enantioselective biotransformation of metalaxyl in plants. In this study, a sensitive and convenient chiral liquid chromatography-tandem mass spectrometry method was developed for simultaneous measurement of the enantiomers of metalaxyl and its major metabolite, metalaxyl acid, in tomato and cucumber. Separation was by reversed-phase chromatography on a Chiralcel OD-RH column under isocratic conditions using acetonitrile-water (60/40, v/v) as mobile phase. The proposed method was successfully applied to investigate the possible enantioselective transformation of metalaxyl as well as the formation of metalaxyl acid in tomato and cucumber. In both vegetables, the (-)-R-enantiomer was preferentially degraded, resulting in relative enrichment of the (+)-S-enantiomer. Furthermore, formation of the metalaxyl acid enantiomers was also shown to be enantioselective, with the R-metalaxyl acid formed at a faster rate. This is the first evidence of enantioselective transformation of metalaxyl in vegetables, and the results should be considered in future environmental risk and food safety evaluations.

分类号： TS2

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