Cordyceps militaris polysaccharides can improve the immune efficacy of Newcastle disease vaccine in chicken

文献类型： 外文期刊

第一作者： Wang, Mi

作者： Wang, Mi;Qin, Tao;Hu, Yuanliang;Wang, Mi;Meng, Xinyu;Yang, Ruile;Li, Ying;Zhang, Lifang;Fei, Chengzhong;Zhen, Wenli;Zhang, Keyu;Wang, Xiaoyang;Xue, Feiqun

作者机构：

关键词： Cordyceps militaris polysaccharide;Cytokines;Lymphocyte proliferation;Newcastle disease vaccine;Serum antibody titre

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

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收录情况： SCI

摘要： Cordyceps militaris polysaccharide (CMP) was prepared by water decoction and ethanol precipitation. The fractional CMP_(40) and CMP_(50) were extracted from the CMP solution by stepwise precipitation with ethanol at 40% and 50% of working concentration, respectively. The immune-enhancing activities of two polysaccharides were researched. In vitro experiment, the effects of two polysaccharides on chicken peripheral lymphocyte proliferation were determined by MTT assay. The result displayed that two polysaccharides could significantly stimulate lymphocyte proliferation, the action of CMP_(40) was significantly or numerically stronger than those of CMP_(50). In vivo experiment, 320 14-day-old chickens were averagely divided into eight groups. The chickens, except blank control (BC) group, were vaccinated with Newcastle disease vaccine, repeated vaccination at 28 days old. At the same time of the first vaccination, the chickens in three CMP_(40) fraction groups and three CMP_(50) fraction groups were injected respectively with the polysaccharide at low, medium and high concentrations, in vaccination control (VC) and BC group, with equal volume of physiological saline, once a day for three successive days. On days 7, 14, 21, 28, 35 and 42 after the first vaccination, the lymphocyte proliferation, serum antibody titre and interferon-gamma and interleukin-4 were measured. The results showed that CMP_(40) and CMP_(50) at suitable dose could significantly promote lymphocyte proliferation, enhance serum antibody titre, and improve serum interferon-gamma and interleukin-4 concentrations. It indicated that CMP_(40) fraction and CMP_(50) fraction could significantly improve the immune efficacy of Newcastle disease vaccine, and would be as the candidate of a new-type immune adjuvant.

分类号： Q71

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