Research progress in allele-specific expression and its regulatory mechanisms

文献类型： 外文期刊

第一作者： Gaur, Uma

作者： Gaur, Uma;Mei, Shuqi;Liu, Guisheng;Gaur, Uma;Mei, Shuqi;Liu, Guisheng;Li, Kui

作者机构：

关键词： Phenotypic variation;Allele-specific expression;Regulatory mechanism;Genetic and epigenetic factors

期刊名称：JOURNAL OF APPLIED GENETICS （ 影响因子：3.24； 五年影响因子：2.756 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Although the majority of genes are expressed equally from both alleles, some genes are differentially expressed. Organisms possess characteristics to preferentially express a particular allele under regulatory factors, which is termed allele-specific expression (ASE). It is one of the important genetic factors that lead to phenotypic variation and can be used to identify the variance of gene regulation factors. ASE indicates mechanisms such as DNA methylation, histone modifications, and non-coding RNAs function. Here, we review a broad survey of progress in ASE studies, and what this simple yet very effective approach can offer in functional genomics, and possible implications toward our better understanding of the underlying mechanisms of complex traits.

分类号： Q1

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