Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation

文献类型： 外文期刊

第一作者： Ke, Shaoyong

作者： Ke, Shaoyong;Yang, Ziwen;Wang, Kaimei;Liang, Ying;Shi, Liqiao;Wei, Yanhong

作者机构：

关键词： Antiviral activity;Benzothiazole;Cycloalkylthiophene-imine;Synthesis

期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A series of novel cycloalkylthiophene-imine derivatives containing benzothiazole unit were designed, synthesized and evaluated for their anti-viral activities. The bio-evaluation results indicated that some of the target compounds (such as 5g, 5i, 5u) exhibited good to moderate antiviral effect on CVB5, ADV7 and EV71 viruses, however, these compounds did not have inhibition activity against H1N1 virus. Especially, the compounds 4c and 4d also exhibited high antiviral activities, which provide a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration of active pharmacophores.

分类号： R9

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