Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation

文献类型: 外文期刊

第一作者: Ke, Shaoyong

作者: Ke, Shaoyong;Yang, Ziwen;Wang, Kaimei;Liang, Ying;Shi, Liqiao;Wei, Yanhong

作者机构:

关键词: Antiviral activity;Benzothiazole;Cycloalkylthiophene-imine;Synthesis

期刊名称:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS ( 影响因子:2.823; 五年影响因子:2.677 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: A series of novel cycloalkylthiophene-imine derivatives containing benzothiazole unit were designed, synthesized and evaluated for their anti-viral activities. The bio-evaluation results indicated that some of the target compounds (such as 5g, 5i, 5u) exhibited good to moderate antiviral effect on CVB5, ADV7 and EV71 viruses, however, these compounds did not have inhibition activity against H1N1 virus. Especially, the compounds 4c and 4d also exhibited high antiviral activities, which provide a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration of active pharmacophores.

分类号: R9

  • 相关文献

[1]Design, Synthesis, and Antiviral, Fungicidal, and Insecticidal Activities of Tetrahydro-beta-carboline-3-carbohydrazide Derivatives. Liu, Yongxian,Song, Hongjian,Huang, Yuanqiong,Liu, Yuxiu,Li, Yongqiang,Wang, Qingmin,Li, Jiarui,Yang, Peiwen,Shang, Hui,Song, Yuchuan,Xiao, Zhixin. 2014

[2]Specific ligands for classical swine fever virus screened from landscape phage display library. Yin, Long,Luo, Yuzi,Du, Min,Qiu, Hua-Ji,Yin, Long,Liang, Bo,Wang, Fei,Liu, Aihua,Yin, Long,Wang, Fei,Liu, Aihua,Petrenko, Valery A..

[3]Identification, expression profiling of a grass carp TLR8 and its inhibition leading to the resistance to reovirus in CIK cells. Chen, Xiaohui,Yang, Chunrong,Rao, Youliang,Li, Qingmei,Wan, Quanyuan,Peng, Limin,Su, Jianguo,Wang, Qing,Wu, Shuqin.

[4]Expression analyses and antiviral properties of the Beijing-You and White Leghorn myxovirus resistance gene with different amino acids at position 631. Du, L. X.,Zhao, G. P.,Zhang, C. S..

[5]Antiviral Activity of The Host Restriction Factor Tetherin. Yin Xin,Wang Xiao-Jun,Yin Xin,Wei Ping. 2014

[6]Antiviral potency and functional analysis of tetherin orthologues encoded by horse and donkey. Yin, Xin,Gu, Qinyong,Wei, Ping,Yin, Xin,Guo, Miaomiao,Gu, Qinyong,Wu, Xingliang,Wang, Xiaojun. 2014

[7]Porcine Mx1 fused to HIV Tat protein transduction domain (PTD) inhibits classical swine fever virus infection in vitro and in vivo. Jing, Jiao,Shi, Baojun,Xu, Qianqian,Zhou, Bin,Chen, Puyan,Li, Wenliang,Liu, Ke,Ma, Zhiyong. 2015

[8]Antiviral activity of Eupatorium adenophorum leaf extract against tobacco mosaic virus. Hou, Lingyu,Zhang, Miaozhi,Xie, Xiangming,Tian, Zhaofeng,Cao, Aocheng. 2014

[9]Cloning, expression and antiviral activity of mink alpha-interferons. Zhang, Hai-ling,Zhao, Jian-jun,Chai, Xiu-li,Zhang, Lei,Bai, Xue,Hu, Bo,Liu, Hao,Yan, Xi-jun,Zhang, Dong-liang,Ye, Ming,Wu, Wei. 2015

[10]Antiviral activity of doxycycline against vesicular stomatitis virus in vitro. Wu, Zhuan-chang,Wei, Jian-chao,Li, Bei-bei,Shao, Dong-hua,Li, Yu-ming,Liu, Ke,Shi, Yuan-yuan,Qiu, Ya-feng,Ma, Zhi-yong,Wang, Xin,Zhou, Bin. 2015

[11]Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. Shang, Xiaofei,Li, Maoxing,Li, Maoxing,Ding, Hong,Shang, Xiaofei,Pan, Hu,Miao, Xiaolou. 2011

[12]Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo. Xu, Jinfang,Qian, Ping,Wu, Qunfeng,Liu, Shasha,Fan, Wenchun,Wang, Rong,Zhang, Huawei,Chen, Huanchun,Li, Xiangmin,Xu, Jinfang,Qian, Ping,Wu, Qunfeng,Liu, Shasha,Fan, Wenchun,Wang, Rong,Zhang, Huawei,Chen, Huanchun,Li, Xiangmin,Zhang, Keshan. 2014

[13]A conjugate protein containing HIV TAT, ISG20, and a PRRSV polymerase binding inhibits PRRSV replication and may be a novel therapeutic platform. Liu, Ke,Li, Yuming,Huan, Beili,Shao, Donghua,Wei, Jianchao,Qiu, Yafeng,Li, Beibei,Tong, Guangzhi,Ma, Zhiyong,Zhou, Bin,Wang, Feifei,Qian, Yingjuan,Jung, Yong-Sam,Miao, Denian.

[14]Cloning and expression of mink (Neovison vison) interferon-gamma gene and development of an antiviral assay. Zhang, Hailing,Zhao, Jianjun,Bai, Xue,Zhang, Lei,Hu, Bo,Liu, Hao,Xu, Shujuan,Yan, Xijun,Zhang, Hailing,Yan, Xijun,Zhang, Dongliang,Fan, Sining.

[15]Extracellular expression and antiviral activity of a bovine interferon-alpha through codon optimization in Pichia pastoris. Tu, Yabin,Wang, Gang,Wang, Yanqun,Chen, Weiye,Zhang, Lu,Liu, Yonggang,Jiang, Chenggang,Wang, Shujie,Bu, Zhigao,Cai, Xuehui.

[16]IFN-gamma in turtle: Conservation in sequence and signalling and role in inhibiting iridovirus replication in Chinese soft-shelled turtle Pelodiscus sinensis. Fu, Jian Ping,Chen, Shan Nan,Zou, Peng Fei,Guo, Zheng,Nie, Pin,Fu, Jian Ping,Huang, Bei,Nie, Pin,Zeng, Ling Bing,Qin, Qi Wei. 2014

[17]Short communication: antiviral activity of porcine IFN-lambda 3 against porcine epidemic diarrhea virus in vitro. Shen, Haiyan,Zhang, Chunhong,Liu, Zhicheng,Sun, Minhua,Sun, Junying,Li, Linlin,Dong, Jiawen,Zhang, Jianfeng,Guo, Pengju.

[18]Doxycycline enhances adsorption and inhibits early-stage replication of porcine reproductive and respiratory syndrome virus in vitro. Li, Yuming,Wu, Zhuanchang,Liu, Ke,Qi, Pengfei,Xu, Jinpeng,Wei, Jianchao,Li, Beibei,Shao, Donghua,Shi, Yuanyuan,Qiu, Yafeng,Ma, Zhiyong. 2017

[19]Three novel Anas platyrhynchos avian beta-defensins, upregulated by duck hepatitis virus, with antibacterial and antiviral activities. Lin, Lijuan,Zhang, Kexin,Han, Zongxi,Shao, Yuhao,Liu, Xiaoli,Liu, Shengwang,Ma, Deying,Lin, Lijuan,Zhang, Kexin. 2011

[20]Establishment of a stable CHO cell line with high level expression of recombinant porcine IFN-beta. Chen, Weiye,Hu, Qianqian,Qu, Linmao,Li, HaoBo,Huang, Kehe,Chen, Weiye,Cao, Wenyan,Zhao, Huijun,Hu, Qianqian,Qu, Linmao,Hu, Sen,Ge, Jinying,Wen, Zhiyuan,Wang, Xijun,Li, HaoBo,Bu, Zhigao. 2011

作者其他论文 更多>>