Bioactive Quinic Acid Derivatives from Ageratina adenophora

文献类型： 外文期刊

第一作者： Zheng, Meng-Fei

作者： Zheng, Meng-Fei;Wang, Jing;Lei, Ting;Zhou, Zhong-Yu;Tan, Jian-Wen;Liu, Wan-Xue;Wan, Fang-Hao;Zheng, Meng-Fei;Wang, Jing;Lei, Ting;Xu, Qiao-Lin

作者机构：

关键词： Ageratina adenophora;qunic acid;antimicrobial activity;radical scavenging capacity;DPPH

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A novel quinic acid derivative, 5-O-trans-o-coumaroylquinic acid methyl ester (1), together with three known ones, chlorogenic acid methyl ester (2), macranthoin F (3) and macranthoin G (4), were isolated from the aerial parts of the invasive plant Ageratina adenophora (Spreng.). The structure of new compound 1 was elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 2–4 were isolated from plant A. adenophora for the first time. All the compounds showed in vitro antibacterial activity toward five assayed bacterial strains, especially 3 and 4, which showed in vitro antibacterial activity against Salmonella enterica with MIC values of 7.4 and 14.7 μM, respectively. Compound 1 was further found to display in vitro anti-fungal activity against spore germination of Magnaporthe grisea with an IC_(50) value 542.3 μM. These four compounds were also tested for their antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical.

分类号： O62

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