The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus

文献类型： 外文期刊

第一作者： Schwarz, Erich M.

作者： Schwarz, Erich M.;Williams, Brian A.;Antoshechkin, Igor;Sternberg, Paul W.;Schwarz, Erich M.;Williams, Brian A.;Antoshechkin, Igor;Sternberg, Paul W.;Schwarz, Erich M.;Korhonen, Pasi K.;Campbell, Bronwyn E.;Young, Neil D.;Jex, Aaron R.;Jabbar, Abdul;Hall, Ross S.;Mondal, Alinda;Gasser, Robin B.;Howe, Adina C.;Brown, C. Titus;Pell, Jason;Brown, C. Titus;Hofmann, Andreas;Boag, Peter R.;Zhu, Xing-Quan;Gregory, T. Ryan;Loukas, Alex

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期刊名称：GENOME BIOLOGY （ 影响因子：13.583； 五年影响因子：17.433 ）

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收录情况： SCI

摘要： Background The barber's pole worm, Haemonchus contortus, is one of the most economically important parasites of small ruminants worldwide. Although this parasite can be controlled using anthelmintic drugs, resistance against most drugs in common use has become a widespread problem. We provide a draft of the genome and the transcriptomes of all key developmental stages of H. contortus to support biological and biotechnological research areas of this and related parasites. Results The draft genome of H. contortus is 320 Mb in size and encodes 23,610 protein-coding genes. On a fundamental level, we elucidate transcriptional alterations taking place throughout the life cycle, characterize the parasite's gene silencing machinery, and explore molecules involved in development, reproduction, host-parasite interactions, immunity, and disease. The secretome of H. contortus is particularly rich in peptidases linked to blood-feeding activity and interactions with host tissues, and a diverse array of moleculesis involved in complex immune responses. On an applied level, we predict drug targets and identify vaccine molecules. Conclusions The draft genome and developmental transcriptome of H. contortus provide a major resource to the scientific community for awide range of genomic, genetic, proteomic, metabolomic, evolutionary, biological, ecological, and epidemiological investigations, and a solid foundation for biotechnological outcomes, including new anthelmintics, vaccines and diagnostic tests. This first draft genome of any strongylid nematode paves the way for a rapid acceleration in our understanding of a wide range of socioeconomically important parasites of one of the largest nematode orders.

分类号： Q7

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