文献类型： 外文期刊
第一作者： Huang, Sheng-Zhuo
作者： Huang, Sheng-Zhuo;Ma, Qing-Yun;Dai, Hao-Fu;Zhao, You-Xing;Xu, Feng-Qing;Peng, Hua;Zhou, Jun;Zhang, Xuan;Zheng, Yong-Tang;Huang, Sheng-Zhuo;Ma, Qing-Yun;Dai, Hao-Fu;Zhao, You-Xing
作者机构：
关键词： Excoecaria acerifolia;Euphorbiaceae;Anti-HIV;Diterpenoid;Triterpenoid
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Five new diterpenoids named excocarinols A-E (1-5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58 mu M and SI (Selection Index) over 112.71.
分类号： S759.82
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