Inhibition of virus replication and induction of human tetherin gene expression by equine IFN-alpha 1

文献类型： 外文期刊

第一作者： Hu, Zhe

作者： Hu, Zhe;Wu, Xingliang;Ge, Jinying;Wang, Xiaojun

作者机构：

关键词： Equine IFN-α;Antiviral activities;Equine infectious anemia virus;Equine arteritis virus;Tetherin

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

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收录情况： SCI

摘要： Type I interferons (IFNs) play important roles in the defense of host cells against viral infection by inducing the expression of a diverse range of antiviral factors. IFNs from different animals likely share similar features with human IFNs, and some of them have cross-species activities. Equine IFN-alpha was proved effective in both equine and human cells. However, the previous studies mostly focused on the inhibition of virus induced cytopathic effects. In this study, we used virus-specific assays to demonstrate the antiviral activities of equine IFN-alpha 1 in both equine and human cells. Equine IFN-alpha 1 inhibited the expression of viral structural proteins and the production of virions of equine infectious anemia virus (EIAV) and equine arteritis virus (EAV) in equine cells. In addition, equine IFN-alpha 1 inhibited the production of EIAV virus-like particles (VLP) from human 293T cells. An IFN-inducible human gene, tetherin, was induced in 293T cells by equine IFN-alpha 1. Its induction correlated with the inhibition of VLP release from the cell membrane. This result indicates that equine IFN-alpha 1 shares a similar mechanism of action with human IFN-alpha in regulating antiviral genes expression in human cells

分类号： S85

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