Effect of interleukin-2 level and genetic variants on coronary artery disease

文献类型: 外文期刊

第一作者: Ding, Ru

作者: Ding, Ru;He, Zhiqing;Liang, Chun;Wu, Zonggui;Gao, Wenwu;Ostrodci, David H.;Song, Yuanlin;Ma, Lan

作者机构:

关键词: coronary artery disease;Interleukin-2;polymorphism;serum level

期刊名称:INFLAMMATION ( 影响因子:4.092; 五年影响因子:3.923 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 -330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 -330GG genotype was significantly increased in CAD than in controls (p = 5.1 × 10-6). Function analysis revealed that subjects carrying IL-2 -330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes (p < 0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls (p < 0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected (p < 0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease.

分类号: R3

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