Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets

文献类型: 外文期刊

第一作者: Chen, Gang

作者: Chen, Gang;Zhang, Jun;Zhang, Yuzhe;Liao, Peng;Li, Tiejun;Yin, Yulong;Chen, Gang;Chen, Lixiang;Wang, Jinquan;Wu, Guoyao;Wu, Guoyao

作者机构:

关键词: Monosodium glutamate;Pig;Liver;Gene expression

期刊名称:AMINO ACIDS ( 影响因子:3.52; 五年影响因子:3.6 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: This experiment was conducted to investigate the effects of oral administration of monosodium glutamate (MSG) on expression of genes for hepatic lipid and nitrogen metabolism in piglets. A total of 24 newborn pigs were assigned randomly into one of four treatments (n = 6/ group). The doses of oral MSG administration, given at 8:00 and 18:00 to sow-reared piglets between 0 and 21 days of age, were 0 (control), 0.06 (low dose), 0.5 (intermediate dose), and 1 (high dose) g/kg body weight/ day. At the end of the 3-week treatment, serum concentrations of total protein and high-density lipoprotein cholesterol in the intermediate dose group were elevated than those in the control group (P < 0.05). Hepatic mRNA levels for fatty acid synthase, acetyl-coA carboxylase, insulin-like growth factor-1, glutamate-oxaloacetate transaminase, and glutamate-pyruvate transaminase were higher in the middle-dose group (P < 0.05), compared with the control group. MSG administration did not affect hepatic mRNA levels for hormone-sensitive lipase or carnitine palmitoyl transferase-1. We conclude that oral MSG administration alters hepatic expression of certain genes for lipid and nitrogen metabolism in suckling piglets.

分类号: Q5`Q7

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