Molecular characteristics and evolutionary analysis of field Marek's disease virus prevalent in vaccinated chicken flocks in recent years in China
文献类型: 外文期刊
第一作者: Yu, Zu-Hua
作者: Yu, Zu-Hua;Chi, Jia-Qi;Hu, Bo;Liu, Ju-Xiong;Yu, Zu-Hua;Teng, Man;Luo, Jun;Yu, Le-Le;Su, Jing-Wei;Chi, Jia-Qi;Zhao, Pu;Hu, Bo;Zhang, Gai-Ping;Yu, Zu-Hua;Ding, Ke;Luo, Jun;Wang, Xin-Wei;Su, Jing-Wei
作者机构:
关键词: China;gE;gI;Isolate;MDV;Meq;Phylogenetic analysis
期刊名称:VIRUS GENES ( 影响因子:2.332; 五年影响因子:2.0 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Marek's disease is a highly contagious, oncogenic, and immunosuppressive avian viral disease. Surveillance of newly registered Marek's disease virus (MDV) isolates is meaningful for revealing the potential factors involved in increased virulence. Presently, we have focused on the molecular characteristics of all available MDVs from China, including 17 new Henan isolates. Based on Meq, gE, and gI genes, we found that most Chinese isolates contain conserved amino acid point mutations in Meq, such as E77, A115, A139, R176, and A217, compared to USA virulent MDVs. However, the 59-aa or 60-aa insertions are only found in a few mild MDVs rather than virulent MDVs in China. Further phylogenetic analysis has demonstrated that a different genotype of MDV has been prevalent in China, and for virulent MDVs, their recent evolution has possibly been geographically restricted. Our study has provided more detailed information regarding the field MDVs circulating in China.
分类号: R37
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