Cytotoxicity of melittin and apamin in human hepatic L02 and HepG2 cells in vitro

文献类型: 外文期刊

第一作者: Zhou, Jinhui

作者: Zhou, Jinhui;Diao, Qingyun;Wu, Liming;Du, Xia;Li, Yi;Sun, Liping;Zhou, Jinhui;Wu, Liming;Li, Yi;Zhou, Jinhui;Wu, Liming;Li, Yi;Qi, Yitao

作者机构:

关键词: Apamin;Apoptosis;CCl4 induced-liver injury;HepG2 cell;L02 cell;Melittin

期刊名称:TOXIN REVIEWS ( 影响因子:4.266; 五年影响因子:3.581 )

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收录情况: SCI

摘要: The aim of this study is to investigate whether melittin and apamin exhibit any effect on human hepatic cells (L02 cells) and hepatocellular carcinoma cells (HepG2) growth through apoptosis. The results did not show any cytotoxic effect on the L02 cells but did show a synergistic effect of apamin on liver injury. Moreover, melittin and apamin could inhibit the growth of HepG2 cells in a dose-/time-dependent manner and initiate markedly early apoptosis of HepG2 cells. The results of this study showed melittin and apamin have potential as new therapy of liver cancer.

分类号: R9

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