Molecular characterization of a duck Tembusu virus from China

文献类型： 外文期刊

第一作者： Bai, XiaoFei

作者： Bai, XiaoFei;Lv, Rang;Liu, ChunGuo;Qiu, Na;He, Yilong;Yin, XiuChen;Li, XiaoJun;Liu, Ming;Zhang, Yun

作者机构：

关键词： Cleavage sites;Flavivirus;Secondary structure;Tembusu virus

期刊名称：VIRUS GENES （ 影响因子：2.332； 五年影响因子：2.0 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A new emerging flavivirus caused severe egg-drop in poultry and spread quickly across most duck-producing regions of China in 2010. Complete genome sequencing indicated that the virus genome is 10,989 nucleotides in length and possesses typical flavivirus genome organization, 5′ untranslated region (UTR)-Cv-Ci-prM-M-E-NS1-NS2A-NS2B-NS3-NS4A-2K-NS4B-NS5-3′-UTR. The long open reading frame (ORF) encodes 3,425 amino acids (95-10,372 nt). The 94-nucleotide 5′-UTR is of intermediate size and the 617-nucleotide 3′-UTR is quite long relative to those of other flaviviruses. The polyprotein cleavage sites, potential glycosylation sites, distribution of cysteine residues, and 3′-UTR secondary structure were characterized. Phylogenetic analysis of the polyprotein sequences indicates that the HN isolate is closely related to Tembusu viruses of the Ntaya virus group.

分类号： R37

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