SERS study of different configurations of pharmaceutical and natural product molecules ginsenoside Rg3 under the interaction with human serum albumin on simple self-assembled substrate

文献类型： 外文期刊

第一作者： Zhang, Wei

作者： Zhang, Wei;Wang, Yingping;Hou, Wei;Jin, Yinping;Bai, Xueyuan;Zhao, Yu;Zhao, Daqing;Zhao, Bing

作者机构：

关键词： Ginsenoside Rg3;Human serum albumin;Surface-enhanced Raman scattering;Interaction

期刊名称：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY （ 影响因子：4.098； 五年影响因子：3.464 ）

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收录情况： SCI

摘要： Surface-enhanced Raman scattering (SERS) and fluorescence spectroscopy were employed to probe the interaction of the pharmaceutical and natural product molecules,20(R) and 20(S)-ginsenoside Rg3,with human serum albumin (HSA).Normal Raman spectra of 20(R) and 20(S)-ginsenoside Rg3 were obtained from solid powder on glass slide.Based on the splitting peaks near 1440 cm~(-1),the stacking modes of 20(R) and 20(S)-ginsenoside Rg3 were quite different.SERS spectra of both R and S configurations were obtained from a colloidal silver surface on a self-assembled SERS substrate,the most enhanced modes of 20(R) and 20(S)-ginsenoside Rg3 were those with certain motions perpendicular to the metal surface.The SERS spectra were used to predict a common orientation geometry for the alkyl chain portion of the drugs on the colloidal surface with a minor difference in the carbocyclic rings.Nevertheless,once combined with HSA,the flexible portion of alkyl chains assumes a collectively similar conformation on the Ag surface with the glucose rings perpendicularly plugging into the hydrophobic site of HSA.

分类号： O657.3

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