Association analysis of bovine Foxa2 gene single sequence variant and haplotype combinations with growth traits in Chinese cattle

文献类型： 外文期刊

第一作者： Liu, Mei

作者： Liu, Mei;Li, Mijie;Wang, Shaoqiang;Xu, Yao;Lan, Xianyong;Li, Zhuanjian;Lei, Chuzhao;Chen, Hong;Yang, Dongying;Jia, Yutang;Li, Mijie;Li, Mijie

作者机构：

关键词： Association;Cattle;Foxa2 gene;Growth traits;Haplotype combination;Sequence variant

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

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年卷期：

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收录情况： SCI

摘要： Forkhead box A2 (Foxa2) has been recognized as one of the most potent transcriptional activators that is implicated in the control of feeding behavior and energy homeostasis. However, similar researches about the effects of genetic variations of Foxa2 gene on growth traits are lacking. Therefore, this study detected Foxa2 gene polymorphisms by DNA pool sequencing, PCR-RFLP and PCR-ACRS methods in 822 individuals from three Chinese cattle breeds. The results showed that four sequence variants (SVs) were screened, including two mutations (SV1, g. 7005 C>T and SV2, g. 7044 C>G) in intron 4, one mutation (SV3, g. 8449 A>G) in exon 5 and one mutation (SV4, g. 8537 T>C) in the 3'UTR. Notably, association analysis of the single mutations with growth traits in total individuals (at 24. months) revealed that significant statistical difference was found in four SVs, and SV4 locus was highly significantly associated with growth traits throughout all three breeds (P< 0.05 or P< 0.01). Meanwhile, haplotype combination CCCCAGTC also indicated remarkably associated to better chest girth and body weight in Jiaxian Red cattle (P< 0.05). We herein described a comprehensive study on the variability of bovine Foxa2 gene that was predictive of molecular markers in cattle breeding for the first time.

分类号： R394

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