Virus-encoded miR-155 ortholog is an important potential regulator but not essential for the development of lymphomas induced by very virulent Marek's disease virus
文献类型: 外文期刊
第一作者: Yu, Zu-Hua
作者: Yu, Zu-Hua;Teng, Man;Yu, Le-Le;Hu, Bo;Zhang, Gai-Ping;Luo, Jun;Yu, Zu-Hua;Hu, Bo;Liu, Ju-Xiong;Zhang, Gai-Ping;Sun, Ai-Jun;Cui, Zhi-Zhong;Qu, Liang-Hu;Yu, Zu-Hua;Ding, Ke;Cheng, Xiang-Chao;Luo, Jun
作者机构:
关键词: MDV;MicroRNA;miR-155;mdvl-miR-M4;BAC;Pathogenesis;Oncogenesis
期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The microRNA (miRNA) mdvl-miR-M4, a functional miR-155 ortholog encoded by oncogenic Marek's disease virus (MDV), has previously been suggested to be involved in MDV pathogenesis. Using the technique of bacterial artificial chromosome mutagenesis, we have presently evaluated the potential role of mdvl-miR-M4 in the oncogenesis of the very virulent (w) MDV strain GX0101. Unexpectedly, deletions of the Meq-cluster or mdvl-miR-M4 alone from the viral genome strongly decreased rather than abolished its oncogenicity. Compared to GX0101, mortalities of mutants GXAmiR-M4 and GXAMeq-miRs were reduced from 100% to 18% and 4%, coupled with the gross tumor incidence reduction from 28% to 22% and 8%, respectively. Our data suggests that the mdvl-miR-M4 is possibly an important regulator in the development of Marek's disease (MD) lymphomas but is not essential for the oncogenicity of wMDV. In addition, some of the other Meq-clustered miRNAs may also play potentially critical roles in wMDV induction of lymphomas.
分类号: R37
- 相关文献
作者其他论文 更多>>
-
The combination of metabolome and transcriptome clarifies the inhibition of the Alternaria toxin accumulation by methyl ferulate
作者:Ge, Shuai;Xie, Ying;Ding, Ke;Xu, Saiqing;Xu, Haishan;Chang, Xia;Shan, Yang;Ding, Shenghu;Ge, Shuai;Xie, Ying;Ding, Ke;Xu, Saiqing;Xu, Haishan;Chang, Xia;Li, Huan;Shan, Yang;Ding, Shenghu;Wang, Rongrong;Luo, Zisheng
关键词:Alternaria alternata; Alternaria toxin; Methyl ferulate; Transcriptome; Metabolome
-
Rapid detection and quantification of melamine, urea, sucrose, water, and milk powder adulteration in pasteurized milk using Fourier transform infrared (FTIR) spectroscopy coupled with modern statistical machine learning algorithms
作者:Chu, Chu;Wang, Haitong;Luo, Xuelu;Fan, Yikai;Nan, Liangkang;Du, Chao;Gao, Dengying;Wen, Peipei;Wang, Dongwei;Yang, Zhuo;Yang, Guochang;Liu, Li;Li, Yongqing;Zhang, Shujun;Hu, Bo;Zunongjiang, Abula
关键词:Pasteurized milk; Fourier transform infrared (FTIR) spectroscopy; Modern statistical machine learning algorithms; Adulteration
-
Genome-wide identification of Saccharum Sec14-like PITP gene family reveals that ScSEC14-1 is positively involved in disease resistance
作者:Su, Yachun;Feng, Jingfang;You, Chuihuai;Zang, Shoujian;Wang, Wei;Wang, Dongjiao;Mao, Huaying;Chen, Yao;Luo, Jun;Que, Youxiong;Su, Yachun;Su, Yachun;Sun, Tingting;Que, Youxiong
关键词:Sugarcane; Phosphatidylinositol transfer protein (PITP); Genome-wide identification; Pathogen infection; Disease resistance
-
Developing new sugarcane varieties suitable for mechanized production in China: principles, strategies and prospects
作者:Que, Youxiong;Wu, Qibin;Zhang, Yuebin;Que, Youxiong;Wu, Qibin;Que, Youxiong;Wu, Qibin;Zhang, Hua;Luo, Jun
关键词:sugarcane; sugar industry; mechanized production; varieties; prospect
-
A method for screening CDV microneutralization activity in microvolume samples
作者:Deng, Xiaoyu;Hu, Bo;Bai, Xue;Su, Jiazi;Bai, Xue
关键词:CDV microneutralizing activity; Microneutralizing activity screening method; Microvolume samples; Neutralizing antibody
-
Quality characteristics and nutrient contents of Bactrian camel milk as determined by mid-infrared spectroscopy
作者:Li, Yongqing;Liu, Li;Fan, Yikai;Hao, Leixiao;Zou, Huiying;Wang, Haitong;Yang, Zhuo;Chu, Chu;Zhang, Shujun;Li, Yongqing;Liu, Li;Xieermaola, Yeerlan;Cao, Lijun;Na, Jia;Wufuer, Gulire;Hu, Bo;Abula, Zunongjiang;Liu, Weihua;Yang, Qi;Wen, Wan;Li, Weiqi
关键词:Mid-infrared spectroscopy; MIRS; Bactrian camel; Milk composition; Minerals; Casein
-
Effect of GnRH Active Immunisation on Reproductive Performance of Male Sprague Dawley Rats
作者:Zhang, Cheng-Qi;Li, Shuang-Shuang;Hu, Bo;Xu, Li-Wen;Liu, Jia-Jia;Sun, Ya-Jie;Bai, Xue
关键词:GnRH; active immunisation; testosterone; rats