Heavy Metal Influence on BDE-47 Uptake in the Human KERTr Keratinocyte Cell Line

文献类型： 外文期刊

第一作者： Kang, Yuan

作者： Kang, Yuan;Zhang, Qiu Yun;Li, Lai Sheng;Zeng, Li Xuan;Luo, Ji Wen;Kang, Yuan;Wong, Ming Hung;Kang, Yuan;Wong, Ming Hung;Yin, Yi

作者机构：

关键词： uptake;PBDEs;KERTr;heavy metals

期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Significant correlations between concentrations of PBDEs and heavy metals were observed in the human body. However, there is a lack of evidence on the linkage between the uptake of heavy metals and PBDEs. This study is the first report on the BDE-47 uptake profile in a human cell line. Hg and As exposures to KERTr (human skin derived keratinocyte) did not significantly (p[0.05) affect the uptake of BDE47, whereas Pb and Cd significantly (p\0.05) affected the uptake of BDE-47 in KERTr. The change in Km was minor after exposure to all heavy metals. The maximum transport rate (V_(max)) after exposure to Pb (V_(max): 5.23 ± 0.49) and As (V_(max): 4.95 ± 0.60) was significantly increased when compared with the background of the KERTr cell line (V_(max): 4.07 ± 0.35). Real-time RT-PCR indicated that OATP-B, OATP-D, and OATP-E were expressed in the KERTr cell line. The upregulation or downregulation of OATP B and D genes were minor after exposure to heavy metals, but the OATP E gene was upregulated by three to fourfold in KERTr cell line after exposure to Pb an Cd, which may explain the significant increase of uptake of BDE-47 in KERTr after exposures to Pb and Cd. This study indicated that the uptake effects should be considered when performing risk assessment of human exposure to PBDEs and heavy metal. # 2013 Wiley Periodicals, Inc. Environ Toxicol 29: 354-361, 2014.

分类号： R9

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