Characterization of an avian influenza virus of subtype H4N6 isolated from ducks in the northern China

文献类型： 外文期刊

第一作者： Xu, Chuantian

作者： Xu, Chuantian;Hu, Beixia;Yang, Shaohua;Huang, Qinghua;Zhang, Lin;Zhang, Xiumei;Lu, Mei

作者机构：

关键词： Avirulent;Evolutionary relationships;H4N6 avian influenza;Replicate

期刊名称：VIRUS GENES （ 影响因子：2.332； 五年影响因子：2.0 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： In 2010, an H4N6 avian influenza virus (AIV) was isolated and identified from healthy ducks in a waterfowl market in Shandong Province in the northern China. This virus was named A/duck/Shandong/1/2010 (H4N6) (DK/SD/1/2010 hereafter). The gene sequence of the virus was determined, and genetic and evolutionary analyses were conducted by combining related sequences in GenBank. Results indicated that seven genes of DK/SD/1/2010 (PB2, PB1, PA, HA, NP, M, and NS) originate from the Eurasian lineage. Another gene, the NA gene, originated from both the Eurasian and the North American lineages. The amino acid sequence near the cleavage site of DK/SD/1/2010 HA (PKKASR↓GLF) corresponded to the characteristics of AIV of low pathogenicity. Animal inoculation tests showed that the virus cannot replicate in chickens and mice. Therefore, DK/SD/1/2010 may be a recombinant virus formed by influenza virus genes from different sources through complicated restructuring and evolution in ducks that is avirulent to chickens and mice.

分类号： R37

  • 相关文献

[1]Rapid differentiation of Ralstonia solanacearum avirulent and virulent strains by cell fractioning of an isolate using high performance liquid chromatography. Zheng, Xuefang,Lin, Naiquan,Zheng, Xuefang,Zhu, Yujing,Liu, Bo,Yu, Qian.

[2]The complete mitochondrial genome of Chionodraco hamatus (Notothenioidei: Channichthyidae) with phylogenetic consideration. Song, Wei,Li, Lingzhi,Huang, Hongliang,Meng, Yongyong,Jiang, Keji,Zhang, Fengying,Chen, Xuezhong,Ma, Lingbo. 2016

[3]Genetic diversity and evolutionary relationship analyses within and among Raphanus species using EST-SSR markers. Wang, Qingbiao,Zhang, Li,Zheng, Pengjing,Wang, Qingbiao,Zhang, Li,Zheng, Pengjing.

作者其他论文 更多>>

微信小程序