Synthesis and antitumor properties of novel curcumin analogs

文献类型： 外文期刊

第一作者： Luo, Hui

作者： Luo, Hui;Yang, Shengjie;Luo, Hui;Yang, Shengjie;Zhao, Qi;Xiang, Hongmei;Luo, Hui;Yang, Shengjie;Zhao, Qi;Xiang, Hongmei

作者机构：

关键词： Curcumin analogs;Antitumor;Apoptosis;Flow cytometry analysis

期刊名称：MEDICINAL CHEMISTRY RESEARCH （ 影响因子：1.965； 五年影响因子：1.98 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A series of novel curcumin (CC) analogs were synthesized by reacting substituted aldehydes with intermediates 4a and 4b. The inhibitory activities of these CC analogs were investigated on human cancer cells PC3, Bcap-37, and MGC-803 in vitro by MTT assay. The results showed that most of the title compounds displayed moderate to high levels of antitumor activities. Compound 5f, the most active CC analogs, has the IC_(50) values of 1.34 ± 0.28, 3.90 ± 0.36, and 0.86 ± 0.44 uM against the three human cancer cells assayed, respectively. Furthermore, subsequent fluorescence staining and flow cytometry analysis indicated compound 5f could induce apoptosis in PC3, Bcap-37, and MGC-803 cells, and the apoptosis ratio reachs the peak (27.1 %) in MGC-803 cells at 24 h after treatment at 10 muM.

分类号： R9

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