Origin and characteristics of the recombinant novel avian infectious bronchitis coronavirus isolate ck/CH/LJL/111054

文献类型： 外文期刊

第一作者： Liu, Shengwang

作者： Liu, Shengwang;Xu, Qianqian;Han, Zongxi;Liu, Xiaoli;Li, Huixin;Guo, Hongbo;Sun, Nana;Shao, Yuhao;Kong, Xiangang

作者机构：

关键词： Avian infectious bronchitis virus;Recombinant event;Connecticut serotype;Massachusetts serotype

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.342； 五年影响因子：3.188 ）

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收录情况： SCI

摘要： Recombination among infectious bronchitis viruses (IBVs), coupled with point mutations, insertions, and deletions that occur in the genome, is thought to contribute to the emergence of new IBV variants. In this study an IBV, ck/CH/LJL/111054, was isolated from a H120-vaccinated chicken, which presented with a suspected IBV infection. Phylogenetic analysis of the S1 subunit sequence confirmed that strain ck/CH/LJL/111054 is of the Connecticut-type; however, further extensive full-length genomic analysis identified the occurrence of recombination events. Therefore, strain ck/CH/LJL/111054 may have originated from recombination events between Conn- and Mass-like strains at three recombination breakpoints: two located within the nsp3 gene sequence and one in the nsp12 gene sequence. Further, the uptake of the 5 ' untranslated regions, nsp2, parts of nsp3, nsp4-11, and parts of nsp 12 from Mass-like virus by ck/ CH/LJL/111054 might have resulted in changes in viral replication efficiency rather than antigenic changes, via cross-neutralization analysis with the H120 strain. Recombination events coupled with the accumulation of mutations in the ck/CH/LJL/111054 genome may account for its increased virulence in specific-pathogen free chickens

分类号： R1

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