A Convenient Synthesis and Biological Activity of Novel Pyrido[4,3-d] pyrimidin-4(3H)-ones

文献类型： 外文期刊

第一作者： Ren, Qingyun

作者： Ren, Qingyun;Gu, Yucheng;He, Hongwu;Shi, YanXia;Li, Baoju;Gu, Yucheng

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关键词： compounds;display;moderate

期刊名称：JOURNAL OF HETEROCYCLIC CHEMISTRY （ 影响因子：2.193； 五年影响因子：1.645 ）

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收录情况： SCI

摘要： Fifteen novel 2-alkylamino-3-aryl-8-cyano-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidin-4(3H)-ones 6a-6o were designed and have been successfully synthesized via tandem aza-Wittig and annulation reactions with the corresponding iminophosphorances 4, aryl isocyanate, and amines in good yields. Their structures were clearly verified by IR, ~1H NMR, EI-MS spectroscopy and elemental analysis, and in the case of compound 6i, analyzed by single-crystal X-ray diffraction further. The preliminary results of an in vivo bioassay showed that some compounds display moderate antifungal activity.

分类号： O62

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