Enantioselective determination of carboxyl acid amide fungicide mandipropamid in vegetables and fruits by chiral LC coupled with MS/MS

文献类型： 外文期刊

第一作者： Zhang, Hu

作者： Zhang, Hu;Wang, Xiangyun;Wang, Xinquan;Qian, Mingrong;Xu, Mingfei;Xu, Hao;Qi, Peipei;Wang, Qiang;Zhang, Hu;Wang, Xiangyun;Wang, Xinquan;Qian, Mingrong;Xu, Mingfei;Xu, Hao;Qi, Peipei;Wang, Qiang;Zhuang, Shulin

作者机构：

关键词： Absolute configuration;Chiral analysis;Enantiomers;LC-MS/MS;Mandipropamid

期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： An efficient enantioselective method for the determination of mandipropamid in vegetables and fruits was presented by LC coupled with MS/MS. The mandipropamid residues in samples (potato, pepper, grape, and watermelon) were extracted with acetonitrile containing 1% acetic acid. An aliquot was cleaned up with primary and secondary amine and C18 sorbent. Complete enantioseparation of mandipropamid enantiomers in <4 min was obtained on a Lux Cellulose-2 column at 25℃ using methanol with 0.1% formic acid/0.1% aqueous formic acid solution (85:15, v/v) as mobile phase. Good linearity was obtained over the concentration range of 0.5-250 μg/L for each enantiomer in the standard solution and sample matrix calibration curves. Quantification was achieved using matrix-matched standard calibration curves. The interday mean recoveries, intraday repeatability, and interday reproducibility varied from 76.4 to 97.1%, 3.4 to 9.4%, and 3.5 to 11.4%, respectively. The limits of quantification for mandipropamid enantiomers in vegetables and fruits were both 1 μg/kg. Moreover, the absolute configuration of mandipropamid enantiomers was determined by the combination of experimental and predicted electronic circular dichroism spectra, and the first eluted enantiomer was confirmed as (R)-mandipropamid on five chiral columns.

分类号： O6

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