SNP and haplotype analysis reveal IGF2 variants associated with growth traits in Chinese Qinchuan cattle

文献类型： 外文期刊

第一作者： Huang, Yong-Zhen

作者： Huang, Yong-Zhen;Zhan, Zhao-Yang;Li, Xin-Yi;Wu, Sheng-Ru;Sun, Yu-Jia;Xue, Jing;Lan, Xian-Yong;Lei, Chu-Zhao;Chen, Hong;Zhang, Chun-Lei;Jia, Yu-Tang

作者机构：

关键词： Cattle;IGF2;Haplotype;Association analysis;Growth traits

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

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收录情况： SCI

摘要： Insulin-like growth factor 2 (IGF2) is a potent cell growth and differentiation factor and is implicated in mammals' growth and development. The objective of this study was to evaluate the effects of the mutations in the bovine IGF2 with growth traits in Chinese Qinchuan cattle. Four single nucleotide polymorphisms (SNPs) were detected of the bovine IGF2 by DNA pool sequencing and forced polymerase chain reaction-restriction fragment length polymorphism (forced PCR-RFLP) methods. We also investigated haplotype structure and linkage disequilibrium (LD) coefficients for four SNPs in 817 individuals representing two main cattle breeds from China. The result of haplotype analysis showed eight different haplotypes and 27 combined genotypes within the study population. The statistical analyses indicated that the four SNPs, combined genotypes and haplotypes are associated with the withers height, body length, chest breadth, chest depth and body weight in Qinchuan cattle population (P < 0.05 or < 0.01). The mutant-type variants and mutant haplotype (Hap 8: ATGG; likely to be the beneficial QTN allele) was superior for growth traits; the heterozygote diplotype was associated with higher growth traits compared to wild-type homozygote. Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program.

分类号： Q7

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