Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

文献类型： 外文期刊

第一作者： Huang, Sheng-Zhuo

作者： Huang, Sheng-Zhuo;Ma, Qing-Yun;Dai, Hao-Fu;Zhao, You-Xing;Huang, Sheng-Zhuo;Peng, Hua;Hu, Jiang-Miao;Zhou, Jun;Zhang, Xuan;Zheng, Yong-Tang

作者机构：

关键词： Excoecaria acerifolia;Euphorbiaceae;Excoecafolin;Anti-HIV-1;Chemotaxonomy

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerzfolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 mu M, SI >1,836.9,431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.

分类号： S759.82

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