Adenovirus-mediated CCL20/IL-15 gene transfer enhances antitumor immunity in mice

文献类型： 外文期刊

第一作者： Liu, Guang-yao

作者： Liu, Guang-yao;Liu, Ming-yuan;Wang, Xue-lin;Li, Yang;Li, Zhi-jie;Jia, Qiu-ying;Li, Ya-gang;Zhang, Meng-meng;Liu, Ming-yuan

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关键词： Bicistronic adenovirus;Cancer immunotherapy;CCL20;Chemokines;IL-15

期刊名称：IMMUNOBIOLOGY （ 影响因子：3.144； 五年影响因子：3.18 ）

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收录情况： SCI

摘要： The CCL20 chemokine has potent antitumor activities through chemoattracting immature dentritic cells. But the maturation status of tumoral dentritic cells is important limiting factors in DC-based immunity. The endogenous availability of IL-15 was effective in inducing the dentritic cells maturation and IL-15 also shows tumor-specific antitumor activities. We constructed a CCL20/IL-15 bicistronic adenovirus (Ad-CCL20-IL-15) and confirmed its combined antitumor effect in vitro and in vivo. Intratumoral injection of Ad-CCL20-IL-15 into both CT-26 and B16F10 cells resulted in marked reduction of tumor growth in our model. Splenocytes treated by Ad-CCL20-IL-15 developed tumor-specific cytotoxic T cells and IFN-γ secretion could protect mice from rechallenging. This study suggests that CCL20/IL-15 can induce a strong antitumor immune response in tumor tissues and it is a suitable candidate for cancer immunotherapy.

分类号： R392

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