Enhanced antitumor immunity is elicited by adenovirus-mediated gene transfer of CCL21 and IL-15 in murine colon carcinomas

文献类型： 外文期刊

第一作者： Zhao, Dong-xu

作者： Zhao, Dong-xu;Zhao, Kun-chi;Liu, Ming-yuan;Li, Yang;Li, Zhi-jie;Li, Ya-gang;Zhang, Meng-meng;Zhang, Yang;Zhang, Xiao-na;Yu, Xiao-wei;Liu, Ming-yuan

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关键词： Bicistronic adenovirus;Cancer immunotherapy;CCL21;Chemokines;IL-15

期刊名称：CELLULAR IMMUNOLOGY （ 影响因子：4.868； 五年影响因子：4.706 ）

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收录情况： SCI

摘要： The chemokine CCL21 is a potent chemoattractant for T cells and dendritic cells. IL-15 elicits powerful antitumor immune responses through the stimulation of natural killer cells. We constructed a CCL21/IL-15-expressing adenovirus (Ad-CCL21-IL-15) and evaluated its antitumor effects in vitro and in vivo. We found that the intratumoral injection of Ad-CCL21-IL-15 into murine colon carcinomas significantly inhibited tumor growth. Splenocytes from mice treated with Ad-CCL21-IL-15 developed tumor-specific cytotoxic T cells and were protected from subsequent challenges with tumor cells. This study indicates that providing cancer therapy by combining CCL21 and IL-15 can induce antitumor immune responses and is an effective strategy for cancer immunotherapy.

分类号： Q2

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