Design, Synthesis and Bioactivity of Novel Glycosylthiadiazole Derivatives

文献类型： 外文期刊

第一作者： Zong, Guanghui

作者： Zong, Guanghui;Zhao, Hanqing;Jiang, Rui;Zhang, Jianjun;Liang, Xiaomei;Wang, Daoquan;Zhao, Hanqing;Li, Baoju;Shi, Yanxia

作者机构：

关键词： 1;3;4-thiadiazole;carbohydrates;synthesis;fungicidal activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A series of novel glycosylthiadiazole derivatives, namely 2-phenylamino-5- glycosyl-1,3,4-thiadiazoles, were designed and synthesized by condensation between sugar aldehydes A/B and substituted thiosemicarbazide C followed by oxidative cyclization by treating with manganese dioxide. The original fungicidal activities results showed that some title compounds exhibited excellent fungicidal activities against Sclerotinia sclerotiorum (Lib.) de Bary and Pyricularia oryzae Cav, especially compounds F-5 and G-8 which displayed better fungicidal activities than the commercial fungicide chlorothalonil. At the same time, the preliminary studies based on the Elson-Morgan method indicated that many compounds exhibited some inhibitory activity toward glucosamine-6- phosphate synthase (GlmS). The structure-activity relationships (SAR) are discussed in terms of the effects of the substituents on both the benzene and the sugar ring.

分类号： O62

  • 相关文献

[1]Synthesis, Biological Evaluation, and Structure-Activity Relationship Study of Novel Stilbene Derivatives as Potential Fungicidal Agents. He, Daohang,Jian, Weilin,Liu, Xianping,Shen, Huifang,Song, Shaoyun.

[2]Design, synthesis and fungicidal activity of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamide. Xu, Yan,Du, Juan,Yang, Xin-Ling,Xu, Gao-Fei,Ling, Yun,Yuan, Hui-Zhu.

[3]Structural diversity-guided convenient construction of functionalized 4H-1,3,4-oxadiazin-5(6H)-one derivatives. Ke, Shaoyong,Wang, Kaimei,Zhang, Zhigang,Zhang, Ya-Ni,Liang, Ying,Shi, Liqiao,Jiang, Aibing,Yang, Ziwen.

[4]Over-expression of (1,3;1,4)--D-glucanase isoenzyme EII gene results in decreased (1,3;1,4)--D-glucan content and increased starch level in barley grains. Han, Ning,Na, Chenglong,Chai, Yuqiong,Chen, Jianshu,Zhang, Zhongbo,Bai, Bin,Bian, Hongwu,Zhu, Muyuan,Zhang, Yuhong.

[5]Synthesis and antibacterial activity of oxime ester derivatives containing 1,2,4-triazole or 1,3,4-oxadiazole moiety. Wang, Xiaobin,Zhong, Xinmin,Zhu, Xuesong,Li, Qin,Zhang, Juping,Ruan, Xianghui,Xue, Wei,Wang, Hua.

[6]Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. Shi, Yan-Xia,Li, Bao-Ju,Wang, Bao-Lei,Ma, Yi,Liu, Xing-Hai,Li, Yong-Hong,Song, Hai-Bin,Li, Zheng-Ming.

[7]Microwave Assistant Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing Pyridine Moiety. Sun, Guo-Xiang,Wu, Hong-Ke,Yang, Ming-Yan,Sun, Zhao-Hui,Liu, Xing-Hai,Shi, Yan-Xia,Li, Bao-Ju,Zhang, Yong-Gang. 2014

[8]Synthesis and Fungicidal Activities of Azaindolyl Thiazoline Compounds. Xiao Yumei,Yuan Dekai,Zhang Zhenhua,Fu Bin,Yan Xiaojing,Yuan Huizhu. 2016

[9]Synthesis, Structure Characterization and Fungicidal Activity of 1,3-Disubstituted-1H-1,2,4-triazole-5-amines. Jia Changqing,Xu Yanjun,Liu Jiping,Qin Zhaohai,Su Wangcang. 2016

[10]Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety. Tong Jianying,Sun Nabo,Liu Xinghai,Sun Nabo,Shi Yanxia,Li Baoju. 2012

[11]Design, synthesis and fungicidal activity of 11-alkoxyimino-5,6-dihydro-dibenzo[b,e] azepine-6-one derivatives. Xu, Yan-jun,Huang, Jia-xing,Liang, Xiao-mei,Zhang, Jian-jun,Wang, Dao-quan,Yan, Xiao-jing,Yuan, Hui-zhu.

[12]Synthesis and Fungicidal Activity of 2-Alkylaminosulfonyl-5,6-dihydro-dibenzo[b,e]azephine-6,11-dione. . 2014

[13]Synthesis and Fungicidal Activity of Aryl Carbamic Acid-5-aryl-2-furanmethyl Ester. Li, Ying,Ling, Yun,Miao, Hong-Jian,Yang, Xin-Ling,Li, Bao-Ju,Shi, Yan-Xia.

[14]Synthesis and Fungicidal Activity of Novel 2,5-Disubstituted-1,3,4-oxadiazole Derivatives. Cui, Zi-Ning,Zhang, Li,Ling, Yun,Yang, Xin-Ling,Shi, Yan-Xia,Li, Bao-Ju,Cui, Zi-Ning,Nishida, Yoshihiro. 2012

[15]Synthesis and Fungicidal Activity of Novel N-Nitro-2-pyrimidinamine Derivatives. Zhao, Jian,Gao, Beibei,Chen, Shuo,Jiang, Zhifu,Ning, Jun,Yuan, Huizhu,She, Dongmei. 2013

[16]Synthesis and Biological Activities of 1,2,3-Thiadiazole Derivatives Containing 1,3,4-Thiadiazole Moiety. Wang Shouxin,Wang Shouxin,Zuo Xiang,Fan Zhijin,Zhang Zhengcai,Zhang Jufang,Xiong Lixia,Fu Yifeng,Fang Zhen,Wu Qingjun,Zhang Youjun. 2013

[17]Design, synthesis and bioactivities of novel oxime ether derivatives. Yang, Junjiao,Xie, Ruliang,Zhang, Tao,Mei, Xiangdong,Ning, Jun. 2013

[18]Synthesis and fungicidal activity of macrolactams and macrolactones with an oxime ether side chain. Jia, Yue-Mei,Liang, Xiao-Mei,Zhu, Wei-Juan,Zhang, Jian-Jun,Dong, Yan-Hong,Wu, Jin-Ping,Chen, Fu-Heng,Wang, Dao-Quan,Yuan, Hui-Zu,Qi, Shu-Hua. 2007

[19]Synthesis of some new N-pyridylpyrazoles and determination of their fungicidal activity. Zhao, Yu,Wang, Gang,Dong, Weili,Wang, Suhua,Li, Zhengming,Shi, Yanxia,Li, Baoju. 2010

[20]Design, Synthesis, and Fungicidal Activity of Macrolactones and Macrolactams with a Sulfonamide Side Chain. Wu, Peng,Liang, Xiao-Mei,Dong, Yan-Hong,Zhang, Jian-Jun,Meng, Xiang-Qing,Wu, Jin-Ping,Chen, Fu-Heng,Wang, Dao-Quan,Yuan, Hui-Zu,Qi, Shu-Hua.

作者其他论文 更多>>

微信小程序