Effects of dietary wheat bran arabinoxylans on cholesterol metabolism of hypercholesterolemic hamsters

文献类型： 外文期刊

第一作者： Tong, Li-Tao

作者： Tong, Li-Tao;Zhong, Kui;Liu, Liya;Guo, Lina;Zhou, Xianrong;Zhou, Sumei;Qiu, Ju;Cao, Li;Cao, Li

作者机构：

关键词： Wheat bran arabinoxylans;Oat β-glucan;Hypercholesterolemia;Fecal lipids;Short-chain fatty acids;Hamsters

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

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收录情况： SCI

摘要： The aim of the present study is to investigate the effects of dietary wheat bran arabinoxylans (AXs) on cholesterol metabolism in hypercholesterolemic hamsters. The hamsters were divided into 3 groups and fed the experimental diets containing AXs or oat β-glucan at a dose of 5 g/kg for 30 days. As the results, the AXs lowered plasma total cholesterol and LDL-cholesterol concentrations, and increased excretions of total lipids, cholesterol and bile acids, as well as oat β-glucan. The AXs reduced the activity of 3-hydroxy-3-methyl glutaryl-coenzyme A (HMG-CoA) reductase, and increased the activity of cholesterol 7-α hydroxylase (CYP7A1) in liver. Moreover, the AXs increased propionate and the total short-chain fatty acids (SCFAs) concentrations. These results indicated that dietary AXs reduced the plasma total cholesterol and LDL-cholesterol concentrations by promoting the excretion of fecal lipids, regulating the activities of HMG-CoA reductase and CYP7A1, and increasing colonic SCFAs in hamsters.

分类号： O629`Q53

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